幕下多发性硬化病变中“中央静脉征”的研究
Investigation of the "central vein sign" in infratentorial multiple sclerosis lesions.
作者信息
Weber Claudia E, Sandikci Vesile, Ebert Anne, Szabo Kristina, Platten Michael, Gass Achim, Eisele Philipp
机构信息
Department of Neurology, Medical Faculty Mannheim and Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Theodor-Kutzer-Ufer 1 - 3, 68167 Mannheim, Germany.
出版信息
Mult Scler Relat Disord. 2020 Oct;45:102409. doi: 10.1016/j.msard.2020.102409. Epub 2020 Jul 17.
BACKGROUND
Recently there has been an increasing interest in the "central vein sign" (CVS) in multiple sclerosis (MS) lesions. Infratentorial brain regions represent typical predilection sites for MS lesion development and are part of the current McDonald criteria to demonstrate dissemination in space, but only a few studies investigated the presence of the CVS in infratentorial MS lesions. The aim of this study was to investigate the CVS in infratentorial MS lesions.
METHODS
3T MRI data sets from 119 patients with relapsing MS were analysed. Chronic lesions were identified on T2-weighted images. Co-registered T2 / susceptibility-weighted images (SWI) were analysed for the presence of the CVS.
RESULTS
A total of 527 lesions were analysed. A CVS was present in the majority of infratentorial lesions (62/88, 70%). There was no difference in the frequencies of the CVS of infratentorial lesions compared to paraventricular lesions (67/81, 83%; p = 0.06) or subcortical (150/209; 72%; p = 0.82) lesions. Infratentorial lesions showed a CVS more often than juxtacortical lesions (16/34; 47%; p = 0.02), while periventricular lesions showed a CVS more often than infratentorial lesions (97/115; 84%, p = 0.02).
CONCLUSION
CVS is a frequent finding in infratentorial MS lesions that may increase the diagnostic value in MS.
背景
近年来，多发性硬化症（MS）病灶中的“中央静脉征”（CVS）越来越受到关注。幕下脑区是MS病灶发展的典型好发部位，也是当前用于证明空间扩散的麦克唐纳标准的一部分，但仅有少数研究调查了幕下MS病灶中CVS的存在情况。本研究的目的是调查幕下MS病灶中的CVS。
方法
分析了119例复发型MS患者的3T MRI数据集。在T2加权图像上识别慢性病灶。对配准后的T2/磁敏感加权成像（SWI）进行分析，以确定是否存在CVS。
结果
共分析了527个病灶。大多数幕下病灶（62/88，70%）存在CVS。与脑室旁病灶（67/81，83%；p = 0.06）或皮质下病灶（150/209；72%；p = 0.82）相比，幕下病灶中CVS的出现频率无差异。幕下病灶比皮质旁病灶更常出现CVS（16/34；47%；p = 0.02），而脑室周围病灶比幕下病灶更常出现CVS（97/115；84%，p = 0.02）。
结论
CVS在幕下MS病灶中很常见，可能会提高MS的诊断价值。
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