Department of Neonatology, John Hunter Children's Hospital, Lookout Road, New Lambton Heights, New South Wales 2305, Australia; University of Newcastle, Newcastle, Australia.
Department of Neonatology, John Hunter Children's Hospital, Lookout Road, New Lambton Heights, New South Wales 2305, Australia; University of Newcastle, Newcastle, Australia.
Clin Perinatol. 2020 Sep;47(3):529-547. doi: 10.1016/j.clp.2020.05.010. Epub 2020 May 15.
Primary function of cardiovascular system is to meet body's metabolic demands. The aim of inotrope therapy is to minimise adverse impact of cardiovascular compromise. Current use of inotropes is primarily guided by the pathophysiology of cardiovascular compromise and anticipated actions of inotropes. Lack of significant reduction in morbidity and mortality associated with cardiovascular compromise despite inotrope use, highlights major gaps in our understanding of circulatory targets, thresholds and choices of inotrope therapy. Thus far, prevention of cardiovascular compromise remains the most effective strategy to optimize outcomes. Studies of alternative design are needed for further advancement in cardiovascular therapy in neonates.
心血管系统的主要功能是满足身体的代谢需求。正性肌力药物治疗的目的是尽量减少心血管功能障碍的不良影响。目前，正性肌力药物的使用主要是根据心血管功能障碍的病理生理学和正性肌力药物的预期作用来指导的。尽管使用了正性肌力药物，但心血管功能障碍相关的发病率和死亡率并没有显著降低，这突出表明我们对循环目标、阈值和正性肌力药物治疗选择的理解存在重大差距。到目前为止，预防心血管功能障碍仍然是优化结果的最有效策略。需要进行其他设计的研究，以推动新生儿心血管治疗的进一步发展。
