Vedder Viviana L, Aherrahrou Zouhair, Erdmann Jeanette
Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany.
Front Cardiovasc Med. 2020 Jun 30;7:109. doi: 10.3389/fcvm.2020.00109. eCollection 2020.
Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of atherosclerosis models and highlight the potential for future studies on inflammatory responses in lipid deposits in zebrafish, based on known immune reactions in humans and mice, in anticipation of new zebrafish models with more advanced atherosclerotic plaques.
心血管疾病，如动脉粥样硬化，是全球主要的死亡原因。尽管小鼠目前是动脉粥样硬化最常用的模型，但斑马鱼正逐渐成为一种替代模型，尤其适用于炎症和脂质代谢研究。在此，我们回顾动脉粥样硬化模型的历史，并基于人类和小鼠已知的免疫反应，强调未来对斑马鱼脂质沉积中炎症反应进行研究的潜力，以期获得具有更先进动脉粥样硬化斑块的新型斑马鱼模型。
