School of Natural Resources, University of Nebraska-Lincoln , Lincoln, NE, USA.
School of Biological Sciences, University of Nebraska-Lincoln , Lincoln, NE, USA.
Prion. 2020 Dec;14(1):185-192. doi: 10.1080/19336896.2020.1796250.
PRNP genotypes, number of octarepeats (PHGGGWGQ) and indels in the PRNP promoter can influence the progression of prion disease in mammals. We found no relationship between presence of promoter indels in white-tailed deer and mule deer from Nebraska and CWD presence. White-tailed deer with the 95 H allele and G20D mule deer were more likely to be CWD-free, but unlike other studies white-tailed deer with the 96S allele(s) were equally likely to be CWD-free. We provide the first information on PRNP genotypes and indels in the promoter for Key deer (all homozygous 96SS) and Coues deer (lacked 95 H and 96S alleles, but possessed a uniquely high frequency of 103 T). All deer surveyed were homozygous for three tandem octarepeats.
PRNP 基因型、八聚体重复次数（PHGGGWGQ）和 PRNP 启动子中的插入缺失与哺乳动物朊病毒病的进展有关。我们发现内布拉斯加州白尾鹿和骡鹿的启动子插入缺失与 CWD 的存在之间没有关系。携带 95H 等位基因和 G20D 等位基因的白尾鹿更有可能不携带 CWD，但与其他研究不同的是，携带 96S 等位基因的白尾鹿也同样有可能不携带 CWD。我们首次提供了基鹿（均为纯合子 96SS）和郊鹿（缺乏 95H 和 96S 等位基因，但独特地具有高频率的 103T）的 PRNP 基因型和启动子插入缺失信息。所有被调查的鹿均为三个串联八聚体重复的纯合子。
