Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia.
Medical School, University of Western Australia, Crawley, Western Australia, Australia.
Osteoporos Int. 2020 Dec;31(12):2439-2448. doi: 10.1007/s00198-020-05556-0. Epub 2020 Jul 27.
Adiposity has a complex relationship with bone health. In 4865 Australian baby boomers (2642 females) aged 45-70 years, we found that higher visceral adipose tissue mass is associated with reduced bone density adjusting for body mass and lifestyle factors, suggesting that excess visceral fat may be deleterious to bone.
Increased body mass is associated with higher bone mineral density (BMD), but higher visceral adipose tissue (VAT) may have a negative impact on bone health. In the Busselton Healthy Ageing Study, we examined associations between VAT mass and BMD in 4865 participants (2642 females) aged 45-70 years.
VAT mass and BMD of whole body, total hip, femoral neck and lumbar spine were measured using DXA. VAT mass was examined as a continuous variable and in quartiles using sex-specific cut-offs.
The mean age was 58.0 ± 5.8 years. Males had significantly higher BMI (28.3 ± 3.7 vs 27.5 ± 4.9 kg/m) and VAT mass (1675 ± 878 vs 882 ± 600 g) than females (both P < 0.001). In males, after adjustment for age, body mass, height and lifestyle factors, VAT mass negatively associated with total body, total hip and femoral neck BMD (β = - 0.153 to - 0.293, all P < 0.001). Males in the highest quartile of VAT mass (> 2200 g) had significantly lower BMD at all three sites than those in lower quartiles, with estimated BMD differences of 2.3-5.7% (all P < 0.05). In females, VAT mass negatively associated with total body, femoral neck and lumbar spine BMD (β = - 0.067 to - 0.178, all P < 0.05) and those in the highest quartile (> 1250 g) had significantly lower total body BMD than other quartiles (by 1.7-3.7%, all P < 0.05).
In middle-aged Australians, after covariate adjustment, higher DXA-derived VAT mass is associated with reduced bone density, suggesting that excess visceral fat may be deleterious to bone, especially in males.
体脂与骨骼健康有着复杂的关系。在 4865 名年龄在 45-70 岁的澳大利亚生育高峰期出生的人群（2642 名女性）中，我们发现内脏脂肪组织质量较高与骨密度降低有关，这与身体质量和生活方式因素有关，这表明过多的内脏脂肪可能对骨骼有害。
体重增加与更高的骨矿物质密度（BMD）有关，但更高的内脏脂肪组织（VAT）可能对骨骼健康产生负面影响。在比弗顿健康老龄化研究中，我们检查了 4865 名参与者（2642 名女性）的 VAT 质量与 BMD 之间的关系，这些参与者年龄在 45-70 岁之间。
使用 DXA 测量全身、全髋、股骨颈和腰椎的 VAT 质量和 BMD。VAT 质量被作为连续变量和四分位数进行检查，使用性别特异性的截断值。
平均年龄为 58.0±5.8 岁。男性的 BMI（28.3±3.7 比 27.5±4.9kg/m）和 VAT 质量（1675±878 比 882±600g）明显高于女性（均 P<0.001）。在男性中，在调整年龄、身体质量、身高和生活方式因素后，VAT 质量与全身、全髋和股骨颈 BMD 呈负相关（β=-0.153 至-0.293，均 P<0.001）。VAT 质量最高四分位组（>2200g）的男性在所有三个部位的骨密度明显低于低四分位组，估计 BMD 差异为 2.3-5.7%（均 P<0.05）。在女性中，VAT 质量与全身、股骨颈和腰椎 BMD 呈负相关（β=-0.067 至-0.178，均 P<0.05），最高四分位组（>1250g）的女性全身 BMD 明显低于其他四分位组（差异为 1.7-3.7%，均 P<0.05）。
在澳大利亚中年人群中，经过协变量调整后，DXA 衍生的 VAT 质量较高与骨密度降低有关，这表明过多的内脏脂肪可能对骨骼有害，尤其是在男性中。
