Department of Neurosurgery, Global Neurosciences Institute, 3100 Princeton Pike Ste D, Lawrenceville, NJ, 08648, USA.
Curr Nutr Rep. 2020 Sep;9(3):258-263. doi: 10.1007/s13668-020-00332-2.
In this review, we examine the postulated mechanisms of therapeutic effect of ketogenic diets in the treatment of gliomas, review the completed clinical trials, and discuss further directions in this field.
Cancers including gliomas are characterized by derangements in cellular metabolism. In vitro and animal studies have revealed that dietary interventions to reduce glucose and glycolytic pathways in gliomas may have a therapeutic effect. Early trials in patients with malignant gliomas have shown feasibility, but are not robust enough yet to demonstrate clinical applicability. Therapies for malignant gliomas of the brain are increasingly using a multi-targeted approach. The use of ketogenic diets and its variants may offer a unique and promising anti-glioma treatment by exploiting metabolic alterations seen in cancers including gliomas seen at the cellular level, which may work in concert with other therapies.
在本次综述中，我们探讨了生酮饮食治疗脑胶质瘤的可能作用机制，回顾了已完成的临床试验，并讨论了该领域的进一步方向。
包括脑胶质瘤在内的癌症的特征是细胞代谢的紊乱。体外和动物研究表明，减少脑胶质瘤中葡萄糖和糖酵解途径的饮食干预可能具有治疗作用。恶性脑胶质瘤患者的早期试验显示了其可行性，但还不够强大，无法证明其临床适用性。脑恶性胶质瘤的治疗越来越多地采用多靶点方法。生酮饮食及其变体的使用可能通过利用在细胞水平上观察到的包括脑胶质瘤在内的癌症中的代谢改变，提供一种独特且有前景的抗脑胶质瘤治疗方法，与其他治疗方法协同作用。
