Rare Disease and Birth Defects Unit, Department of Woman, Child Health and Public Health, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Child Neurology Unit, Department of Woman, Child Health and Public Health, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Obes Surg. 2021 Jan;31(1):445-450. doi: 10.1007/s11695-020-04882-w. Epub 2020 Jul 28.
Pregnancy after bariatric surgery is usually considered safe. Recently, a few studies reported that bariatric surgery represents a risk factor for birth defects. A case series of six patients, born from women who had undergone biliopancreatic diversion, is reported. The clinical pattern was characterized by psychomotor development delay (100%), microphthalmia (83%), growth retardation (66%), hearing loss (66%), and variable facial dysmorphism. Based on the clinical profile and symptoms reported by women during pregnancy, a causal association between maternal chronic post-surgical malabsorption, congenital anomalies, and neonatal outcome is proposed, with vitamin A deficiency representing a major causing factor. Educational follow-up support, continuous clinical monitoring, and appropriate nutritional assessment appear to be crucial to reduce the potential risk of congenital malformations and child disability.
肥胖症手术治疗后的妊娠通常被认为是安全的。最近，有几项研究报告称，肥胖症手术治疗是出生缺陷的一个危险因素。本文报道了 6 例接受胆胰分流术的女性所生婴儿的病例系列，其临床特征为精神运动发育迟缓（100%）、小眼（83%）、生长迟缓（66%）、听力损失（66%）和不同程度的面部畸形。基于女性在妊娠期间报告的临床特征和症状，提出了母体慢性术后吸收不良、先天性异常和新生儿结局之间的因果关系，维生素 A 缺乏是主要致病因素。教育随访支持、持续的临床监测和适当的营养评估对于降低先天性畸形和儿童残疾的潜在风险至关重要。
