新布奥苷 A 和 B，两种具有α-淀粉酶抑制活性的来自 的新型咖啡酸糖苷。
Newboulasides A and B, two new caffeic acid glycosides from with α-amylase inhibitory activity.
机构信息
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Anambra State, Nigeria.
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu State, Nigeria.
出版信息
Nat Prod Res. 2022 Feb;36(3):726-734. doi: 10.1080/14786419.2020.1799362. Epub 2020 Jul 28.
Chemical investigation of the ethanol extract of the leaves of (P. Beauv) led to the isolation of two new caffeic acid glycosides, Newboulasides A and B . The structures of these compounds were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. The extracts and fractions and the isolated compounds were evaluated for their inhibition of α-amylase enzyme activity. The extract showed inhibition of α-amylase activity with IC value of 102.91 µg/mL, while the isolated compounds ( and exhibited pronounced inhibition with IC values of 4.95 and 4.44 µg/mL respectively, comparable to the standard - Acarbose with IC value of 4.05 µg/mL. Our findings demonstrated that the inhibition of α-amylase activity may be part of the mechanisms through which exhibits antidiabetic effect.
（毕氏马唐）叶的乙醇提取物的化学成分研究导致了两种新的咖啡酸糖苷的分离，即 Newboulasides A 和 B。这些化合物的结构是基于广泛的光谱方法确定的，包括 1D-NMR、2D-NMR 和 MS 数据。提取物和馏分以及分离得到的化合物都进行了α-淀粉酶酶抑制活性的评估。提取物对α-淀粉酶活性的抑制作用的 IC 值为 102.91 µg/mL，而分离得到的化合物（ 和 ）表现出明显的抑制作用，IC 值分别为 4.95 和 4.44 µg/mL，与标准阿卡波糖的 IC 值 4.05 µg/mL 相当。我们的研究结果表明，α-淀粉酶活性的抑制可能是 发挥抗糖尿病作用的部分机制。
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