从吕宋荚蒾中分离得到的五种新酚苷。
Five New Phenolic Glycosides from Viburnum luzonicum.
作者信息
Chen Jia, Zhao Min, Zhou Hongjuan, Tang Yiyuan, Ji Wei, Shao Jianhua, Zhao Chunjie, Zhao Chunchao
机构信息
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Joint International Research Laboratory of Agriculture & Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China.
出版信息
Chem Biodivers. 2023 Apr;20(4):e202300246. doi: 10.1002/cbdv.202300246. Epub 2023 Apr 19.
Viburnum luzonicum is widely distributed in China. Its branch extracts showed potential α-amylase and α-glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A-E (1-5), were obtained by bioassay-guided isolation coupled with HPLC-QTOF-MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α-amylase and α-glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α-amylase (IC =17.5 μM) and α-glucosidase (IC =13.6 μM).
吕宋荚蒾在中国分布广泛。其枝条提取物显示出潜在的α-淀粉酶和α-葡萄糖苷酶抑制活性。为了发现新的生物活性成分，通过生物活性导向分离结合HPLC-QTOF-MS/MS分析，获得了5个未描述的酚苷，即荚蒾皂苷A-E（1-5）。通过光谱分析，包括一维核磁共振、二维核磁共振、电子圆二色光谱和旋光色散，阐明了它们的结构。对所有化合物进行了α-淀粉酶和α-葡萄糖苷酶抑制活性测试。化合物1对α-淀粉酶（IC =17.5 μM）和α-葡萄糖苷酶（IC =13.6 μM）表现出显著的竞争性抑制作用。
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