McCobb D P, Cohan C S, Connor J A, Kater S B
Department of Biology, University of Iowa, Iowa City 52242.
Neuron. 1988 Jul;1(5):377-85. doi: 10.1016/0896-6273(88)90187-0.
Serotonin (5-HT) inhibits elongation of neurites of specific identified neurons. Here we report a novel, growth-enabling action of another neurotransmitter, acetylcholine (ACh). When applied simultaneously with serotonin, ACh prevents the inhibition of Helisoma neuron B19 neurite elongation that would occur in response to application of 5-HT alone. We also report that ACh prevents the rise in growth cone Ca2+ that would occur in response to application of 5-HT alone and that ACh blocks the electrical excitatory effect of 5-HT on neuron B19. These results support the hypothesis that growth cone motility and neurite elongation can be regulated by voltage-gated Ca2+ fluxes and suggest that the dynamics of neurite morphology may be complexly regulated by an array of neurotransmitters, as is functional electrical activity.
血清素（5-羟色胺）会抑制特定已识别神经元的神经突伸长。在此，我们报告了另一种神经递质乙酰胆碱（ACh）的一种新的促生长作用。当与血清素同时应用时，乙酰胆碱可防止单独应用5-羟色胺时所发生的对扁卷螺神经元B19神经突伸长的抑制作用。我们还报告称，乙酰胆碱可防止单独应用5-羟色胺时所发生的生长锥钙离子浓度升高，并且乙酰胆碱可阻断5-羟色胺对神经元B19的电兴奋作用。这些结果支持了这样一种假说，即生长锥运动性和神经突伸长可由电压门控钙离子通量调节，并表明神经突形态的动态变化可能像功能性电活动一样受到一系列神经递质的复杂调节。
