Harris G L, Henderson L P, Spitzer N C
Department of Biology, University of California, San Diego, La Jolla 92093.
Neuron. 1988 Oct;1(8):739-50. doi: 10.1016/0896-6273(88)90172-9.
Single-channel K+ currents were recorded from young and mature spinal neurons cultured from Xenopus embryos to examine the bases of the developmental increases in density and in rate of activation of the macroscopic voltage-dependent delayed rectifier K+ current (IKv). K+ channels of three conductance classes (integral of 80, 30, and 15 pS) are present at both ages, but only the intermediate and small conductance classes are voltage-dependent and thus underlie IKv. The increase in the density of IKv is due to increases in the numbers of intermediate and small channels per cell, but not to changes in their open probabilities. The increase in rate of activation of IKv results from a change in the activation kinetics of the intermediate channel class alone.
为了研究非洲爪蟾胚胎培养的年轻和成熟脊髓神经元中，宏观电压依赖性延迟整流钾电流（IKv）密度和激活速率发育性增加的基础，记录了单通道钾电流。两个年龄段均存在三种电导类型（积分分别为80、30和15 pS）的钾通道，但只有中间电导和小电导类型是电压依赖性的，因此构成了IKv。IKv密度的增加是由于每个细胞中中间和小通道数量的增加，而非其开放概率的变化。IKv激活速率的增加仅源于中间通道类型激活动力学的改变。
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