Institut de Neurobiologie de la Méditerranée (INMED), Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 901, Parc Scientifique de Luminy, Marseille CEDEX 09, France.
Trends Neurosci. 2010 Nov;33(11):485-92. doi: 10.1016/j.tins.2010.08.005. Epub 2010 Sep 21.
Nervous system development proceeds by sequential gene expression mediated by cascades of transcription factors in parallel with sequences of patterned network activity driven by receptors and ion channels. These sequences are cell type- and developmental stage-dependent and modulated by paracrine actions of substances released by neurons and glia. How and to what extent these sequences interact to enable neuronal network development is not understood. Recent evidence demonstrates that CNS development requires intermediate stages of differentiation providing functional feedback that influences gene expression. We suggest that embryonic neuronal functions constitute a series of phenotypic checkpoint signatures; neurons failing to express these functions are delayed or developmentally arrested. Such checkpoints are likely to be a general feature of neuronal development and constitute presymptomatic signatures of neurological disorders when they go awry.
神经系统的发育是通过级联转录因子介导的基因表达顺序进行的，同时伴随着受体和离子通道驱动的网络活动模式序列。这些序列与细胞类型和发育阶段有关，并受神经元和神经胶质释放的旁分泌物质的调节。这些序列如何以及在何种程度上相互作用以促进神经元网络的发育尚不清楚。最近的证据表明，中枢神经系统的发育需要分化的中间阶段，提供影响基因表达的功能反馈。我们认为，胚胎神经元的功能构成了一系列表型检查点特征；未能表达这些功能的神经元会被延迟或发育停滞。这种检查点可能是神经元发育的一般特征，当它们出错时，就成为神经紊乱的先兆特征。
