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通过综合生物信息学分析鉴定与肝细胞癌发病机制和预后相关的潜在枢纽基因

Identification of potential hub genes associated with the pathogenesis and prognosis of hepatocellular carcinoma via integrated bioinformatics analysis.

作者信息

Meng Ziqi, Wu Jiarui, Liu Xinkui, Zhou Wei, Ni Mengwei, Liu Shuyu, Guo Siyu, Jia Shanshan, Zhang Jingyuan

机构信息

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

出版信息

J Int Med Res. 2020 Jul;48(7):300060520910019. doi: 10.1177/0300060520910019.

DOI:10.1177/0300060520910019
PMID:32722976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7391448/
Abstract

OBJECTIVE

The objective was to identify potential hub genes associated with the pathogenesis and prognosis of hepatocellular carcinoma (HCC).

METHODS

Gene expression profile datasets were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between HCC and normal samples were identified via an integrated analysis. A protein-protein interaction network was constructed and analyzed using the STRING database and Cytoscape software, and enrichment analyses were carried out through DAVID. Gene Expression Profiling Interactive Analysis and Kaplan-Meier plotter were used to determine expression and prognostic values of hub genes.

RESULTS

We identified 11 hub genes (, , , , , , , , , , and ) that might be closely related to the pathogenesis and prognosis of HCC. Enrichment analyses indicated that the DEGs were significantly enriched in metabolism-associated pathways, and hub genes and module 1 were highly associated with cell cycle pathway.

CONCLUSIONS

In this study, we identified key genes of HCC, which indicated directions for further research into diagnostic and prognostic biomarkers that could facilitate targeted molecular therapy for HCC.

摘要

目的

旨在鉴定与肝细胞癌（HCC）发病机制和预后相关的潜在枢纽基因。

方法

从基因表达综合数据库下载基因表达谱数据集。通过综合分析鉴定HCC与正常样本之间的差异表达基因（DEG）。使用STRING数据库和Cytoscape软件构建并分析蛋白质-蛋白质相互作用网络，并通过DAVID进行富集分析。利用基因表达谱交互分析和Kaplan-Meier绘图工具确定枢纽基因的表达和预后价值。

结果

我们鉴定出11个可能与HCC发病机制和预后密切相关的枢纽基因（、、、、、、、、、和）。富集分析表明，DEG在代谢相关途径中显著富集，枢纽基因和模块1与细胞周期途径高度相关。

结论

在本研究中，我们鉴定出了HCC的关键基因，这为进一步研究诊断和预后生物标志物指明了方向，有助于HCC的靶向分子治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/7693f0b7452d/10.1177_0300060520910019-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/7d56210cf1e7/10.1177_0300060520910019-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/a0bafc67bd8d/10.1177_0300060520910019-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/afc76fe5bc2f/10.1177_0300060520910019-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/ef7eeea100c1/10.1177_0300060520910019-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/a17b7853de9f/10.1177_0300060520910019-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/412f7c25e654/10.1177_0300060520910019-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/f7bc58de839f/10.1177_0300060520910019-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/7693f0b7452d/10.1177_0300060520910019-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/7d56210cf1e7/10.1177_0300060520910019-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/a0bafc67bd8d/10.1177_0300060520910019-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/afc76fe5bc2f/10.1177_0300060520910019-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/ef7eeea100c1/10.1177_0300060520910019-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/a17b7853de9f/10.1177_0300060520910019-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/412f7c25e654/10.1177_0300060520910019-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/f7bc58de839f/10.1177_0300060520910019-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade3/7391448/7693f0b7452d/10.1177_0300060520910019-fig8.jpg

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