Department of General Surgery, Cleveland Clinic Florida, Weston, Florida.
Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida.
Surg Obes Relat Dis. 2020 Sep;16(9):1372-1375. doi: 10.1016/j.soard.2020.06.011. Epub 2020 Jul 9.
Tocilizumab, a monoclonal antiinterluekin-6 receptor antibody, has been empirically used in the treatment of cytokine release syndrome associated with severe coronavirus disease 2019 infections. The efficacy and safety of these medications for these patients is unknown. The purpose of this report was to present a case of acute large bowel perforation in a morbidly obese patient with coronavirus disease 2019 pneumonia who received empiric Tocilizumab. This case report analyzes the risks of acute large bowel perforation after using this medication empirically and discusses the appropriate management of this adverse event.
托珠单抗是一种抗白细胞介素-6 受体的单克隆抗体,已被经验性地用于治疗与严重 2019 年冠状病毒病相关的细胞因子释放综合征。这些药物对这些患者的疗效和安全性尚不清楚。本报告的目的是报告一例接受经验性托珠单抗治疗的 2019 年冠状病毒病肺炎肥胖患者并发急性大肠穿孔的病例。本病例报告分析了使用该药物经验性治疗后发生急性大肠穿孔的风险,并讨论了该不良事件的适当处理方法。