Department of Obstetrics and Gynaecology, Bordeaux University Hospital, Place Amélie Rabat Léon, 33000, Bordeaux, France.
CNRS-UMR 5164, ImmunoConcEpT, Bordeaux University, Bordeaux, France.
Sci Rep. 2020 Jul 28;10(1):12611. doi: 10.1038/s41598-020-69191-9.
Our study aimed to assess perinatal outcomes and recurrence rate of Chronic Intervillositis of Unknown Etiology (CIUE). We conducted an observational retrospective study in a tertiary care university hospital in France from January 1, 1997 to July 31, 2018. 122 pregnancies (102 women) with CIUE were included. Cases of the Department of Histopathology placenta database were re-analysed independently by three pathologists specializing in fetal pathology. Diagnosis of CIUE was confirmed according to: (1) the presence of cellular infiltrate in the intervillous space, (2) ~ 80% of the mononuclear cells in the intervillous space positive for CD68, (3) infiltration occupying at least 5% of the intervillous space, and (4) no clinical or histopathological sign of infection. Outcomes of pregnancies with CIUE (miscarriages, stillbirths, terminations of pregnancy, live birth with or without prematurity or fetal growth restriction) and proportion of CIUE recurrence were analysed. The lost pregnancies comprised 17 (13.9%) miscarriages, 17 (13.9%) stillbirths, and 18 (14.8%) terminations of pregnancy. Of the 70 (57.4%) pregnancies that led to a live birth, 38 (54.3%) new-borns were premature and 50 (72.5%) exhibited fetal growth restriction. Among the 102 women, 23 subsequently became pregnant, half of whom (n = 11) developed recurrent CIUE. CIUE was associated with high rates of adverse perinatal outcomes, including pregnancy loss, fetal growth restriction, and preterm birth with a risk of recurrence nearly 50%.
我们的研究旨在评估原因不明的慢性绒毛膜炎（CIUE）的围产期结局和复发率。我们在法国一家三级保健大学医院进行了一项观察性回顾性研究，时间为 1997 年 1 月 1 日至 2018 年 7 月 31 日。共纳入 122 例（102 例女性）CIUE 妊娠。胎盘病理数据库的病例由三位专门从事胎儿病理学的病理学家独立重新分析。CIUE 的诊断依据为：（1）绒毛间隙存在细胞浸润，（2）绒毛间隙中至少 80%的单核细胞 CD68 阳性，（3）浸润至少占绒毛间隙的 5%，（4）无临床或组织病理学感染迹象。分析 CIUE 妊娠的结局（流产、死胎、妊娠终止、活产有无早产或胎儿生长受限）和 CIUE 复发比例。丧失的妊娠包括 17 例（13.9%）流产、17 例（13.9%）死胎和 18 例（14.8%）妊娠终止。70 例（57.4%）导致活产的妊娠中，38 例（54.3%）新生儿早产，50 例（72.5%）有胎儿生长受限。在 102 名女性中，23 人随后再次怀孕，其中一半（n=11）出现复发性 CIUE。CIUE 与不良围产期结局发生率高相关，包括妊娠丢失、胎儿生长受限和早产，复发风险近 50%。
