Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Policy and Economic Research Department, Public Health, Access and Vaccine Epidemiology Unit, International Vaccine Institute, Seoul, Korea.
Clin Infect Dis. 2020 Jul 29;71(Suppl 2):S111-S119. doi: 10.1093/cid/ciaa481.
This article presents a selection of practical issues, questions, and tradeoffs in methodological choices to consider when conducting a cost of illness (COI) study on enteric fever in low- to lower-middle-income countries. The experiences presented are based on 2 large-scale COI studies embedded within the Surveillance for Enteric Fever in Asia Project II (SEAP II), in Bangladesh, Nepal, and Pakistan; and the Severe Typhoid Fever Surveillance in Africa (SETA) Program in Burkina Faso, Ethiopia, Ghana, and Madagascar. Issues presented include study design choices such as controlling for background patient morbidity and healthcare costs, time points for follow-up, data collection methods for sensitive income and spending information, estimating enteric fever-specific health facility cost information, and analytic approaches in combining patient and health facility costs. The article highlights the potential tradeoffs in time, budget, and precision of results to assist those commissioning, conducting, and interpreting enteric fever COI studies.
本文选取了一些实际问题、疑问和方法选择上的权衡，供在中低收入国家开展肠热病疾病负担（COI）研究时考虑。本文所呈现的经验基于两个大型 COI 研究，它们嵌入在亚洲肠热病监测项目 II（SEAP II）中，地点分别为孟加拉国、尼泊尔和巴基斯坦；以及在布基纳法索、埃塞俄比亚、加纳和马达加斯加开展的非洲严重伤寒监测（SETA）项目。本文提出的问题包括研究设计选择，如控制背景患者发病率和医疗保健成本、随访时间点、敏感收入和支出信息的数据收集方法、估计肠热病特定卫生机构成本信息，以及结合患者和卫生机构成本的分析方法。本文强调了在时间、预算和结果精度方面的潜在权衡，以帮助那些委托、进行和解释肠热病 COI 研究的人。
