Kim Hyeon Cheol, Lee Heung Kyu
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
The Center for Epidemic Preparedness, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Vaccines (Basel). 2020 Jul 27;8(3):420. doi: 10.3390/vaccines8030420.
Genital herpes is a venereal disease caused by herpes simplex virus (HSV). Although HSV symptoms can be reduced with antiviral drugs, there is no cure. Moreover, because HSV infected individuals are often unaware of their infection, it is highly likely that they will transmit HSV to their sexual partner. Once infected, an individual has to live with HSV for their entire life, and HSV infection can lead to meningitis, encephalitis, and neonatal herpes as a result of vertical transmission. In addition, HSV infection increases the rates of human immunodeficiency virus (HIV) infection and transmission. Because of the high burden of genital herpes, HSV vaccines have been developed, but none have been very successful. In this review, we discuss the current status of genital herpes vaccine development.
生殖器疱疹是一种由单纯疱疹病毒（HSV）引起的性病。虽然抗病毒药物可以减轻HSV的症状，但无法治愈。此外，由于HSV感染者往往 unaware of their infection（此处原文有误，推测为“往往未意识到自己已感染”），他们很有可能将HSV传染给性伴侣。一旦感染，个体将终生携带HSV，并且HSV感染可能因垂直传播导致脑膜炎、脑炎和新生儿疱疹。此外，HSV感染会增加人类免疫缺陷病毒（HIV）感染和传播的几率。由于生殖器疱疹的高负担，人们已研发出HSV疫苗，但都不太成功。在这篇综述中，我们讨论生殖器疱疹疫苗研发的现状。
