维多珠单抗联合粒细胞和单核细胞吸附性血浆分离术序贯治疗改善难治性溃疡性结肠炎。

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan.

Department of Endoscopy, Nagoya University Hospital, Japan.

Intern Med. 2020 Dec 1;59(23):3009-3014. doi: 10.2169/internalmedicine.5302-20. Epub 2020 Jul 28.

Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no reports of the concomitant use of vedolizumab (VDZ) and GMA for the initial induction of UC. A 20-year-old man with refractory UC was admitted for recrudescence. VDZ monotherapy had previously been introduced but was ineffective. Therefore, he received scheduled combination of VDZ and GMA and achieved clinical remission. The combination of two different approaches to inhibit the migration of leukocytes into the inflamed tissue led to satisfactory clinical outcomes.

粒细胞和单核细胞吸附性血浆分离术（GMA）偶尔被引入作为生物制剂治疗溃疡性结肠炎（UC）患者应答丧失后的一种联合治疗选择。然而，尚无关于维多珠单抗（VDZ）和 GMA 联合用于 UC 初始诱导的报告。一名 20 岁男性，患有难治性 UC 复发，入院治疗。先前已引入维多珠单抗单药治疗，但无效。因此，他接受了维多珠单抗和 GMA 的联合治疗，并达到了临床缓解。两种不同方法联合抑制白细胞迁移到炎症组织，从而获得了满意的临床结果。