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[一名急性髓系白血病儿科患者由喙突弯孢霉引起的鼻窦感染]

[Sinus infection caused by Exserohilum rostratum in a pediatric patient with acute myeloid leukemia].

作者信息

Kral Alejandro, Batalla Kathleen, Santolaya M Elena, Rabello Marcela, Barraza Marlon

机构信息

Facultad de Medicina, Hospital San Borja Arriarán, Universidad de Chile, Chile.

Facultad de Medicina, Hospital Dr. Luis Calvo Mackenna, Universidad de Chile, Chile.

出版信息

Rev Chilena Infectol. 2020 Feb;37(1):77-81. doi: 10.4067/S0716-10182020000100077.

Abstract

The episodes of febrile neutropenia are severe cases that require an exhaustive etiological study and a quick start of antimicrobial agents. Within the possible microorganisms, fungal origins are also found, and depending on its tissue invasion, they can reach a high mortality rate. A case of a pediatric patient who suffered from acute myeloid leukemia is reported, and after his induction chemotherapy, the patient showed an episode of febrile neutropenia, which matches a rhinosinusal infection caused by Exserohilum rostratum, a filamentous fungi that is uncommonly associated with pathological cases. An antifungal therapy and an early surgical treatment were started, which lead to a positive response, without complications to the patient. After the monitoring and receiving secondary prophylaxis during the episodes of neutropenia, the patient hasn't presented new injuries nor rhinosinusal damage.

摘要

发热性中性粒细胞减少症发作属于严重病例,需要进行详尽的病因学研究并迅速启动抗菌药物治疗。在可能的微生物中,也发现有真菌来源,并且根据其组织侵袭情况,它们可能导致较高的死亡率。本文报告了一例患有急性髓系白血病的儿科患者,在其诱导化疗后,患者出现了发热性中性粒细胞减少症发作,这与由喙突弯孢霉引起的鼻窦感染相符,喙突弯孢霉是一种丝状真菌,很少与病理病例相关。开始了抗真菌治疗和早期手术治疗,治疗取得了积极效果,患者未出现并发症。在中性粒细胞减少症发作期间进行监测并接受二级预防后,患者未出现新的损伤或鼻窦损害。

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