Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China.
Biomed Res Int. 2020 Jul 14;2020:5608382. doi: 10.1155/2020/5608382. eCollection 2020.
Lung injury and inflammation are complex pathological processes. The influence and crosstalk between various cells form a characteristic microenvironment. Extracellular vesicles from different cell sources in the microenvironment carry multiple cargo molecules, which affect the pathological process through different pathways. Here, we mainly discussed the mechanism of crosstalk between alveolar epithelial cells and different immune cells through extracellular vesicles in lung inflammation and reviewed the mechanism of extracellular vesicles released by blood and airways on lung inflammation. Finally, the role of extracellular vesicles in viral infection of the lung was also described.
肺损伤和炎症是复杂的病理过程。各种细胞之间的影响和串扰形成了一个特征性的微环境。微环境中不同细胞来源的细胞外囊泡携带多种货物分子，通过不同途径影响病理过程。在这里，我们主要讨论了肺炎症中外泌体通过细胞外囊泡在肺泡上皮细胞和不同免疫细胞之间相互作用的机制，并综述了血液和气道来源的细胞外囊泡在肺炎症中的释放机制。最后还描述了细胞外囊泡在肺部病毒感染中的作用。
