Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.
Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
J Cell Mol Med. 2020 Sep;24(17):9495-9506. doi: 10.1111/jcmm.15608. Epub 2020 Jul 30.
Sepiapterin reductase, a homodimer composed of two subunits, plays an important role in the biosynthesis of tetrahydrobiopterin. Furthermore, sepiapterin reductase exhibits a wide distribution in different tissues and is associated with many diseases, including brain dysfunction, chronic pain, cardiovascular disease and cancer. With regard to drugs targeting sepiapterin reductase, many compounds have been identified and provide potential methods to treat various diseases. However, the underlying mechanism of sepiapterin reductase in many biological processes is unclear. Therefore, this article summarized the structure, distribution and function of sepiapterin reductase, as well as the relationship between sepiapterin reductase and different diseases, with the aim of finding evidence to guide further studies on the molecular mechanisms and the potential clinical value of sepiapterin reductase. In particular, the different effects induced by the depletion of sepiapterin reductase or the inhibition of the enzyme suggest that the non-enzymatic activity of sepiapterin reductase could function in certain biological processes, which also provides a possible direction for sepiapterin reductase research.
蝶呤还原酶是由两个亚基组成的同源二聚体，在四氢生物蝶呤的生物合成中发挥重要作用。此外，蝶呤还原酶在不同组织中广泛分布，并与许多疾病相关，包括脑功能障碍、慢性疼痛、心血管疾病和癌症。关于针对蝶呤还原酶的药物，已经鉴定出许多化合物，为治疗各种疾病提供了潜在的方法。然而，蝶呤还原酶在许多生物过程中的潜在机制尚不清楚。因此，本文总结了蝶呤还原酶的结构、分布和功能，以及蝶呤还原酶与不同疾病的关系，旨在寻找证据，指导对蝶呤还原酶的分子机制和潜在临床价值的进一步研究。特别是，蝶呤还原酶耗竭或酶抑制所诱导的不同效应表明，蝶呤还原酶的非酶活性可能在某些生物过程中发挥作用，这也为蝶呤还原酶的研究提供了一个可能的方向。
