Ades E W, Bosse D, Nicholson J K, Galbraith R
Biological Products Branch, Centers for Disease Control, Atlanta, GA 30333.
Tokai J Exp Clin Med. 1988 Dec;13(6):293-7.
Gc (a vitamin D binding protein) has been speculated to play a role in the function of immune response, yet, it has not been examined for its biological response properties. Therefore, we tried to (a) characterize the appearance of membrane bound Gc (mGc) on non-activated and mitogen activated lymphocytes as well as on Interleukin-2 activated killer cells and (b) examine the role of serum isolated human Gc on human blastogenesis and cytotoxicity (natural killing and lymphokine-activated killing). Our data suggests that activated cells possess a greater number of cells with mGc than non-activated cells and that as a biological response modified we find modulation of blastogenesis and cytotoxicity to be consistently but not very significantly down-regulated. Anti-Gc antibody was observed to significantly inhibit NK activity.
维生素D结合蛋白（Gc）被推测在免疫反应功能中发挥作用，然而，其生物学反应特性尚未得到研究。因此，我们试图（a）描述膜结合Gc（mGc）在未激活和有丝分裂原激活的淋巴细胞以及白细胞介素-2激活的杀伤细胞上的表现，以及（b）研究从血清中分离出的人Gc对人细胞增殖和细胞毒性（自然杀伤和淋巴因子激活的杀伤）的作用。我们的数据表明，与未激活的细胞相比，激活的细胞含有更多带有mGc的细胞，并且作为一种生物学反应修饰，我们发现细胞增殖和细胞毒性的调节持续但不是非常显著地下调。观察到抗Gc抗体可显著抑制自然杀伤活性。
