Bilgic Tayfun
Acibadem Kadikoy Hospital, Istanbul, Turkey.
Int J Low Extrem Wounds. 2021 Mar;20(1):55-59. doi: 10.1177/1534734620938168. Epub 2020 Jul 31.
. To compare the effect of local and systemic injection of resveratrol (RSV) on open cutaneous wound healing. . Open cutaneous wounds were created in adult Sprague-Dawley rats. Group 1 (n = 6) was given intraperitoneal RSV (0.5 mg/kg) once daily for 14 days. Group 2 (n = 6) was given local subcutaneous RSV (0.5 mg/kg) on the wound once daily for 14 days. Group 3 (n = 6) did not receive any pharmacologic agent. Biopsy specimens were obtained on postoperative days (PODs) 7, 14, and 21 and were examined histologically. Wound closure time was recorded. All rats were sacrificed on POD 30 for tensile strength analysis. . The histological scores for collagen deposition, chronic inflammation, and granulation were higher in the systemic and local RSV treatment groups than in the control group. Neovascularization scores significantly increased on PODs 14 and 21 in the local RSV treatment group compared with those in the systemic RSV and control groups. Systemic and local RSV administrations significantly enhanced wound healing and increased the tensile strength of the skin in rats. . Local subcutaneous application of RSV may have a better therapeutic effect than the systemic application of RSV in terms of neovascularization to promote wound healing.
比较局部和全身注射白藜芦醇（RSV）对开放性皮肤伤口愈合的影响。
在成年Sprague-Dawley大鼠身上制造开放性皮肤伤口。第1组（n = 6）每天腹腔注射RSV（0.5毫克/千克），共14天。第2组（n = 6）每天在伤口处局部皮下注射RSV（0.5毫克/千克），共14天。第3组（n = 6）不接受任何药物治疗。在术后第7天、第14天和第21天获取活检标本并进行组织学检查。记录伤口闭合时间。所有大鼠在术后第30天处死以进行拉伸强度分析。
全身和局部RSV治疗组的胶原沉积、慢性炎症和肉芽组织的组织学评分高于对照组。与全身RSV组和对照组相比，局部RSV治疗组在术后第14天和第21天的新生血管化评分显著增加。全身和局部应用RSV均显著促进大鼠伤口愈合并增加皮肤的拉伸强度。
就促进伤口愈合的新生血管化而言，局部皮下应用RSV可能比全身应用RSV具有更好的治疗效果。
