[新型冠状病毒肺炎、糖尿病与肥胖之间的内分泌及代谢联系]

[The endocrine and metabolic link between COVID-19, diabetes and obesity].

作者信息

Weis Nina, Thorsteinsson Kristina, Martinussen Christoffer, Madsbad Sten

出版信息

Ugeskr Laeger. 2020 Jul 13;182(29).

Abstract

Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome corona virus 2. High age, hypertension, diabetes, and obesity are risk factors for severe COVID-19 with increased mortality. In this review, we discuss potential mechanisms by which diabetes and obesity modulate the host viral interactions and host-immune response. Glucose levels should be monitored rigorously, and patient-tailored aggressive treatment of hyperglycaemia is recommended, often with the use of insulin. Persons with diabetes and obesity are susceptible to severe outcomes from COVID-19.

摘要

2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2感染引起。高龄、高血压、糖尿病和肥胖是导致COVID-19病情严重且死亡率增加的危险因素。在本综述中，我们讨论了糖尿病和肥胖调节宿主与病毒相互作用以及宿主免疫反应的潜在机制。应严格监测血糖水平，建议针对患者进行积极的高血糖治疗，通常使用胰岛素。糖尿病和肥胖患者易因COVID-19而出现严重后果。