University of Alberta, Faculty of Rehabilitation Medicine, Dept of Physical Therapy, 3-48 Corbett Hall, Edmonton T6G 2G4, Canada; University of Alberta, Neuroscience and Mental Health Institute, 2-132 Li Ka Shing, Edmonton T6G 2E1, Canada.
University of Alberta, Neuroscience and Mental Health Institute, 2-132 Li Ka Shing, Edmonton T6G 2E1, Canada.
Exp Neurol. 2020 Nov;333:113410. doi: 10.1016/j.expneurol.2020.113410. Epub 2020 Jul 28.
This review is based on a lecture presented at the Craig H. Neilsen Foundation sponsored Spinal Cord Injury Training Program at Ohio State University. We discuss the advantages and challenges of injury models in rodents and theory relation to various behavioral outcome measures. We offer strategies and advice on experimental design, behavioral testing, and on the challenges, one will encounter with animal testing. This review is designed to guide those entering the field of spinal cord injury and/or involved with in vivo animal testing.
这篇综述基于在俄亥俄州立大学 Craig H. Neilsen 基金会赞助的脊髓损伤培训计划的一次演讲。我们讨论了啮齿动物损伤模型的优缺点及其与各种行为结果测量的理论关系。我们提供了关于实验设计、行为测试以及动物测试中遇到的挑战的策略和建议。本综述旨在为那些进入脊髓损伤领域和/或参与体内动物测试的人提供指导。
