脊髓损伤动物模型的行为学测试。
Behavioral testing in animal models of spinal cord injury.
机构信息
University of Alberta, Faculty of Rehabilitation Medicine, Dept of Physical Therapy, 3-48 Corbett Hall, Edmonton T6G 2G4, Canada; University of Alberta, Neuroscience and Mental Health Institute, 2-132 Li Ka Shing, Edmonton T6G 2E1, Canada.
University of Alberta, Neuroscience and Mental Health Institute, 2-132 Li Ka Shing, Edmonton T6G 2E1, Canada.
出版信息
Exp Neurol. 2020 Nov;333:113410. doi: 10.1016/j.expneurol.2020.113410. Epub 2020 Jul 28.
Abstract
This review is based on a lecture presented at the Craig H. Neilsen Foundation sponsored Spinal Cord Injury Training Program at Ohio State University. We discuss the advantages and challenges of injury models in rodents and theory relation to various behavioral outcome measures. We offer strategies and advice on experimental design, behavioral testing, and on the challenges, one will encounter with animal testing. This review is designed to guide those entering the field of spinal cord injury and/or involved with in vivo animal testing.
摘要
这篇综述基于在俄亥俄州立大学 Craig H. Neilsen 基金会赞助的脊髓损伤培训计划的一次演讲。我们讨论了啮齿动物损伤模型的优缺点及其与各种行为结果测量的理论关系。我们提供了关于实验设计、行为测试以及动物测试中遇到的挑战的策略和建议。本综述旨在为那些进入脊髓损伤领域和/或参与体内动物测试的人提供指导。
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J Neurotrauma. 2020 May 1;37(9):1140-1148. doi: 10.1089/neu.2019.6747. Epub 2020 Feb 21.
2
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PLoS One. 2020 Jan 15;15(1):e0226128. doi: 10.1371/journal.pone.0226128. eCollection 2020.
3
FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research.公平科学前进：临床前脊髓损伤研究开放数据共同体的演变。
J Neurotrauma. 2020 Mar 15;37(6):831-838. doi: 10.1089/neu.2019.6674. Epub 2019 Dec 6.
4
Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences.脑干和脊髓中的中枢模式发生器：基本原理、相似性和差异概述。
Rev Neurosci. 2019 Jan 28;30(2):107-164. doi: 10.1515/revneuro-2017-0102.
5
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J Neurotrauma. 2020 Feb 1;37(3):517-527. doi: 10.1089/neu.2018.5959. Epub 2019 Nov 8.
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J Neurotrauma. 2019 Feb 1;36(3):485-499. doi: 10.1089/neu.2018.5713. Epub 2018 Aug 30.
9
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