School of Pharmacy, The University of Auckland, Auckland, New Zealand
Department of Epidemiology and Biostatistics, School of Population Health, The University of Auckland, Auckland, New Zealand.
BMJ Open. 2020 Jul 30;10(7):e035775. doi: 10.1136/bmjopen-2019-035775.
To measure primary medication non-adherence (failure to fill prescription medicines) in patients discharged from the emergency department (ED), and to determine whether sociodemographic factors, smoking status and access to a general practitioner affect prescription filling. Little is known about primary medication non-adherence in EDs, and less so in New Zealand (NZ). Identifying reasons for non-adherence will enable development of strategies to improve adherence and reduce morbimortality.
An observational study based on patient data from the ED of a large public hospital in South Auckland, NZ.
Data were collected from 1600 patients discharged between 28 April-6 May and 28 July-9 August 2014. Data were included if patients were residents within the Auckland Regional Public Health Service boundaries, admitted to ED and discharged with a prescription. Data were excluded if patients were admitted to another ward, transferred to another hospital or left the ED without seeing a doctor.
992 patients were included in the study, the majority were under 10 years (32.6%), of Pacific Island descent (42.8%), NZ-born (67.7%) and living in the most socioeconomically deprived areas (78.1%). Almost 50% of patients failed to fill all prescription medications. Simple linear regression analysis indicated that non-adherence was significant for those 10-24 years (n=236; adherence=47.2%; p<0.05), of NZ Māori ethnicity (n=175; 51.3%; p=0.01), unemployed (n=77; 46.8%; p<0.01), homemakers (n=66; 45.7%; p<0.01), students (n=228; 55.6%; p<0.05) and cigarette smokers (n=139; 50.3%; p<0.01). Following multivariable analysis, the strongest predictors for non-adherence were those aged between 10 and 17 years (n=116; p<0.01), the unemployed (n=77; p=0.01) and homemakers (n=66; p=0.01).
Age and occupation were the greater predictors of non-adherence; however, no other significant differences were found. Since this study, changes to prescription co-payments have been made. Further research is warranted to assess whether this change has more recently affected the rates of non-adherence.
测量从急诊科(ED)出院患者的主要药物不依从性(未填写处方药物),并确定社会人口统计学因素、吸烟状况和获得全科医生的机会是否会影响处方填写。人们对急诊科的主要药物不依从性知之甚少,在新西兰(NZ)更是如此。确定不依从的原因将有助于制定提高依从性和降低发病率和死亡率的策略。
这是一项基于在新西兰南奥克兰一家大型公立医院急诊科患者数据的观察性研究。
2014 年 4 月 28 日至 5 月 6 日和 7 月 28 日至 8 月 9 日期间出院的 1600 名患者的数据被纳入研究。如果患者是奥克兰地区公共卫生服务范围内的居民,入住 ED 并出院时开了处方,则纳入数据。如果患者被转到另一个病房、转到另一家医院或离开 ED 而未看医生,则排除数据。
共有 992 名患者纳入研究,大多数患者年龄在 10 岁以下(32.6%),太平洋岛裔(42.8%),新西兰出生(67.7%),居住在最贫困的地区(78.1%)。近 50%的患者未能填写所有处方药。简单线性回归分析表明,10-24 岁的患者(n=236;依从性=47.2%;p<0.05)、新西兰毛利人(n=175;51.3%;p=0.01)、失业(n=77;46.8%;p<0.01)、家庭主妇(n=66;45.7%;p<0.01)、学生(n=228;55.6%;p<0.05)和吸烟者(n=139;50.3%;p<0.01)的非依从性显著。多变量分析后,非依从性的最强预测因素是 10-17 岁的患者(n=116;p<0.01)、失业者(n=77;p=0.01)和家庭主妇(n=66;p=0.01)。
年龄和职业是不依从的更大预测因素;然而,没有发现其他显著差异。自这项研究以来,处方共付额已发生变化。需要进一步研究以评估这一变化最近是否影响了不依从率。