Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.
Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi 3, 90129, Palermo, Italy.
Eur Arch Otorhinolaryngol. 2021 May;278(5):1577-1583. doi: 10.1007/s00405-020-06223-0. Epub 2020 Jul 31.
Local neck symptoms (LNS) may be related to goiter, but are also reported by patients suffering from laryngeal-pharyngeal reflux (LPR). The aim of this study was to investigate whether LPR could play a role in the persistence of some LNS after total thyroidectomy (TT).
A consecutive case series of 160 patients with multinodular goiter (MNG) candidate for TT were included in this study. Each patient was closely studied for both the thyroid pathology and reflux disease before and 6 months after surgery to assess the persistence of LNS after surgery.
Only throat discomfort showed a significant improvement (p = 0.031) after surgery. On the other hand, swallowing and voice disorders persisted after surgery in 82.3% and 77.3% of patients, respectively (p = 0.250 and p = 0.062), such as the correlated reflux laryngopharyngitis (p = 0.5).
LPR can be considered a predisposing factor or an important concurrent causa to the persistence of LNS after TT, in particular for swallowing disorders and voice disorders. In patients with non-toxic MNG who complain of local neck symptoms, the investigation of a possible coexistence of a reflux disease is appropriate before surgery. Patients should be informed about the possibility that some symptoms can persist even after removal of the goiter.
局部颈部症状(LNS)可能与甲状腺肿有关,但也有报告称喉咽反流(LPR)患者也会出现这种症状。本研究旨在探讨 LPR 是否会在甲状腺全切除术后(TT)某些 LNS 持续存在中起作用。
本研究纳入了 160 例多结节性甲状腺肿(MNG)患者,这些患者均为 TT 候选者。每位患者在手术前和手术后 6 个月都进行了甲状腺病理和反流性疾病的密切研究,以评估手术后 LNS 的持续存在情况。
只有咽喉不适在手术后有明显改善(p = 0.031)。另一方面,吞咽和声音障碍在手术后分别在 82.3%和 77.3%的患者中持续存在(p = 0.250 和 p = 0.062),如相关的反流性喉咽炎(p = 0.5)。
LPR 可被视为 TT 后 LNS 持续存在的诱发因素或重要并发原因,尤其是吞咽障碍和声音障碍。对于非毒性 MNG 患者,若出现局部颈部症状,应在手术前对可能存在反流性疾病进行调查。患者应被告知即使在切除甲状腺肿后,某些症状仍可能持续存在的可能性。