Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou.
Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
J Hypertens. 2021 Jan;39(1):70-76. doi: 10.1097/HJH.0000000000002599.
The aim of this study was to investigate whether the combination of high depressive symptom burden and hypertension increased the risk of stroke among the middle-aged and elderly Chinese using a nationwide prospective study.
Data from the China Health and Retirement Longitudinal Study (CHARLS) during 2011-2015 were used. A total of 12 604 Chinese participants aged 45 years and older were included for final analysis. Multivariate Cox proportional hazards regression model was used to explore the associations between high depressive symptom burden, hypertension and new-onset stroke.
There were 244 stroke events occurred during a 4-year follow-up. Compared with those without high depressive symptom burden and hypertension, the adjusted hazard ratios (95% confidence intervals) were 1.96 (1.13-3.42) for individuals with high depressive symptom burden alone, 2.84 (1.77-4.57) for individuals with hypertension alone and 4.38 (2.66-7.20) for individuals with comorbid high depressive symptom burden and hypertension, respectively. In the subgroup analyses, people with the coexistence of high depressive symptom burden and hypertension had the highest risk of new-onset stroke in all subgroups.
Our results suggest a combined effect of high depressive symptom burden and hypertension on stroke risk among the middle-aged and elderly Chinese.
本研究旨在通过一项全国性前瞻性研究，探讨中老年人中抑郁症状负担高合并高血压是否会增加中风风险。
使用 2011-2015 年中国健康与退休纵向研究（CHARLS）的数据。共纳入 12604 名年龄在 45 岁及以上的中国参与者进行最终分析。采用多变量 Cox 比例风险回归模型探讨高抑郁症状负担、高血压与新发中风之间的关系。
在 4 年的随访期间，发生了 244 例中风事件。与无高抑郁症状负担和高血压的个体相比，仅高抑郁症状负担个体的调整后危险比（95%置信区间）为 1.96（1.13-3.42），仅高血压个体为 2.84（1.77-4.57），高抑郁症状负担和高血压并存个体为 4.38（2.66-7.20）。亚组分析显示，在所有亚组中，同时存在高抑郁症状负担和高血压的人群新发中风的风险最高。
我们的研究结果表明，中老年人中高抑郁症状负担和高血压并存对中风风险有协同作用。
