Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
J Card Surg. 2020 Nov;35(11):3120-3124. doi: 10.1111/jocs.14919. Epub 2020 Aug 2.
Hypertrophic obstructive cardiomyopathy (HOCM) is one of the more common genetic disorders. The pathophysiology and natural history of the disease have been well studied. Left ventricular outflow tract obstruction (LVOTO) and systolic anterior motion (SAM) of the anterior mitral leaflet can result in sudden cardiac death, progressive heart failure and arrythmias. Surgical septal myectomy for HOCM is the standard of care and is routinely performed through a median sternotomy. Septal myectomy has also been performed using the trans-atrial, trans-mitral approach either directly or with robotic assistance. In cases with severe LVOT obstruction in the setting of only mild to moderate proximal septal hypertrophy, intrinsic problems with the mitral valve contribute. Typically, these are hypermobile papillary muscles and or excessive height of the anterior mitral leaflet. Combining septal myectomy with reorientation of hypermobile anteriorly positioned papillary muscles has shown to prevent SAM and thereby additionally decrease the subvalvular aortic outflow obstruction. Our extensive experience in both septal myectomy and robotic mitral valve repair has given us a different perspective in approaching the primary mitral regurgitation in HOCM patients where a combined septal myectomy, papillary muscle reorientation and complex mitral valve repair has been safely performed using the less invasive robotic-assisted approach.Our objective here is to discuss the technical aspects of the procedure.
肥厚型梗阻性心肌病(HOCM)是较为常见的遗传性疾病之一。该病的病理生理学和自然病史已得到充分研究。左心室流出道梗阻(LVOTO)和二尖瓣前叶的收缩期前向运动(SAM)可导致心源性猝死、进行性心力衰竭和心律失常。HOCM 的标准治疗方法是外科室间隔心肌切除术,通常通过正中胸骨切开术进行。也可以通过经心房、经二尖瓣途径直接或借助机器人辅助进行室间隔心肌切除术。在仅存在轻度至中度近端间隔肥厚的情况下存在严重 LVOTO 梗阻的情况下,二尖瓣本身存在问题。通常,这些问题是活动过度的乳头肌和/或前二尖瓣叶的高度过高。室间隔心肌切除术联合活动过度的向前定位的乳头肌重定向已被证明可防止 SAM,从而进一步减少瓣下主动脉流出道梗阻。我们在室间隔心肌切除术和机器人二尖瓣修复方面的丰富经验使我们在处理 HOCM 患者的原发性二尖瓣反流时具有不同的视角,在这些患者中,已经使用微创机器人辅助方法安全地进行了联合室间隔心肌切除术、乳头肌重定向和复杂的二尖瓣修复。我们的目标是在这里讨论该手术的技术方面。