库欣病的医学治疗进展。
Advances in the Medical Treatment of Cushing Disease.
机构信息
Neuroendocrine Unit, Neuroendocrine and Pituitary Tumor Clinical Center, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Suite 140, Boston, MA 02114, USA.
Neuroendocrine Unit, Neuroendocrine and Pituitary Tumor Clinical Center, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Suite 140, Boston, MA 02114, USA.
出版信息
Endocrinol Metab Clin North Am. 2020 Sep;49(3):401-412. doi: 10.1016/j.ecl.2020.05.003. Epub 2020 Jul 2.
Medical therapy has an adjunctive role in management of Cushing disease. Medical therapy is recommended for patients who received pituitary radiotherapy and are awaiting its salutary effects. Medications are used preoperatively to stabilize the condition of seriously ill patients before surgery. Medical therapy is used to control hypercortisolism in patients with uncertain tumor location. Medical therapies available for management of patients with Cushing disease include steroidogenesis inhibitors, centrally acting agents, and glucocorticoid receptor antagonists. All agents require careful monitoring to optimize clinical effectiveness and manage adverse effects. Novel agents in development may expand the armamentarium for management of this condition.
医学治疗在库欣病的治疗中具有辅助作用。对于接受垂体放疗并等待其疗效的患者，建议采用医学治疗。在手术前使用药物来稳定重症患者的病情。对于肿瘤位置不确定的患者，使用药物来控制皮质醇增多症。用于治疗库欣病患者的医学治疗包括类固醇生成抑制剂、中枢作用药物和糖皮质激素受体拮抗剂。所有药物都需要仔细监测，以优化临床效果并处理不良反应。正在开发的新型药物可能会为该疾病的治疗提供更多选择。
Zotero 插件