Kondoh Kunio
Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences.
Basic Sciences Division, Fred Hutchinson Cancer Research Center.
Yakugaku Zasshi. 2020;140(8):985-992. doi: 10.1248/yakushi.20-00012-4.
Central neural circuits in the brain receive and integrate environmental and internal information to enable the animals to execute appropriate behaviors and physiological responses. Communication between the brain and peripheral organs via peripheral neural circuits maintains energy homeostasis in the body. Therefore it is important to investigate the anatomical organization of central and peripheral neural circuits for elucidating the mechanisms of energy homeostasis. Transsynaptic viral tracers can travel through connected neurons via synaptic connections and have been used to delineate the anatomical organization of neural circuits with specific functions. Herein, I review our recent studies investigating neural circuits and their involvement in physiological changes using transsynaptic tracers.
大脑中的中枢神经回路接收并整合环境和内部信息，使动物能够执行适当的行为和生理反应。大脑通过外周神经回路与外周器官之间的通讯维持身体的能量平衡。因此，研究中枢和外周神经回路的解剖组织对于阐明能量平衡机制很重要。跨突触病毒示踪剂可以通过突触连接在相连的神经元之间传播，并已被用于描绘具有特定功能的神经回路的解剖组织。在此，我回顾了我们最近使用跨突触示踪剂研究神经回路及其对生理变化影响的研究。
