Zhu Jiajun, Fu Yu, Tu Guanjun
Department of Orthopedics, The First Affiliated Hospital of China Medical University, Heping, Shenyang, Liaoning 110000, P.R. China.
Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Huanggu, Shenyang, Liaoning 110032, P.R. China.
Exp Ther Med. 2020 Aug;20(2):1675-1681. doi: 10.3892/etm.2020.8832. Epub 2020 Jun 3.
The aim of the present study was to investigate the role of Smad3 inhibitors and the pyroptosis pathway in spinal cord injury, and to determine the underlying mechanism. The pyroptosis signaling pathway may be involved in spinal cord injury during the recovery period. Smad3 inhibitor may serve a role in alleviating spinal cord injury by reducing the pyroptosis of neurons, which is induced by caspase-1, absent in melanoma-2 or NOD-like receptors protein-1 during the recovery period of spinal cord injury. In the present study, spinal cord injury was alleviated by caspase-1 and Smad3 inhibitors. Therefore, a Smad3 inhibitor could relieve spinal cord injury in mice by directly downregulating caspase-1 and reducing neuron pyroptosis following spinal cord injury during the recovery period.
本研究的目的是探讨Smad3抑制剂和细胞焦亡途径在脊髓损伤中的作用，并确定其潜在机制。细胞焦亡信号通路可能参与脊髓损伤恢复期的过程。Smad3抑制剂可能通过减少神经元的细胞焦亡来发挥减轻脊髓损伤的作用，这种细胞焦亡是由半胱天冬酶-1在脊髓损伤恢复期诱导产生的，而黑色素瘤缺乏因子2或NOD样受体蛋白1并不参与此过程。在本研究中，半胱天冬酶-1和Smad3抑制剂减轻了脊髓损伤。因此，Smad3抑制剂可通过在脊髓损伤恢复期直接下调半胱天冬酶-1并减少神经元细胞焦亡来减轻小鼠的脊髓损伤。
