Yamada Yuya, Fujiwara Hiroshi, Banno Haruka, Hikami Kensuke, Nakashima Masakazu, Tamaki Masahiro, Ito Noriyuki
Urology Department Japanese Red Cross Wakayama Medical Center Wakayama Japan.
IJU Case Rep. 2020 Apr 18;3(3):108-111. doi: 10.1002/iju5.12160. eCollection 2020 May.
Although preoperative bradycardia has been reported in several pheochromocytoma cases, postoperative bradycardia has not. This is the first case report of complete atrioventricular dissociation and sinus arrest occurring after pheochromocytoma resection.
A 38-year-old woman was referred for a left adrenal incidentaloma. Twenty-four hour urinary collection showed elevated noradrenaline. Iodine-123-meta-iodobenzylguanidine scintigraphy showed high tracer uptake in the left adrenal region. Open left adrenalectomy was performed, and histopathological examination confirmed the diagnosis of pheochromocytoma. Thirty minutes following surgery, complete atrioventricular dissociation and sinus arrest developed. Vagal reflex attenuation due to decreased noradrenaline after tumor removal and perioperative pain and fear were believed to be the causes. A temporary pacemaker was implanted to prevent sudden death due to vagal overstimulation.
Vagal reflex attenuation after pheochromocytoma resection can result in complete atrioventricular dissociation and sinus arrest. Adequate preoperative preparation and close monitoring during and after surgery are imperative.
尽管已有数例嗜铬细胞瘤患者术前出现心动过缓的报道,但术后心动过缓尚未见报道。本文是首例关于嗜铬细胞瘤切除术后发生完全性房室分离和窦性停搏的病例报告。
一名38岁女性因左肾上腺意外瘤前来就诊。24小时尿儿茶酚胺测定显示去甲肾上腺素水平升高。碘-123-间碘苄胍闪烁显像显示左肾上腺区域有高放射性摄取。行开放性左肾上腺切除术,组织病理学检查确诊为嗜铬细胞瘤。术后30分钟,出现完全性房室分离和窦性停搏。肿瘤切除后去甲肾上腺素减少导致迷走反射减弱以及围手术期疼痛和恐惧被认为是其病因。植入临时起搏器以预防因迷走神经过度刺激导致的猝死。
嗜铬细胞瘤切除术后迷走反射减弱可导致完全性房室分离和窦性停搏。充分的术前准备以及手术期间和术后的密切监测至关重要。