Neurology Department, Hospital Das Clinicas Da FMUSP , Sao Paulo, Brazil.
Neurology Department, Faculdade De Medicina Da Universidade De Sao Paulo , Sao Paulo, Brazil.
Brain Inj. 2020 Jul 28;34(9):1270-1276. doi: 10.1080/02699052.2020.1797166. Epub 2020 Aug 3.
To analyze the influences of mild and severe intracranial hypertension on cerebral autoregulation (CA).
Duroc piglets were monitored with an intracranial pressure (ICP) catheter. Intracranial hypertension was induced via infusion of 4 or 7 ml of saline solution by a bladder catheter that was inserted into the parietal lobe. The static cerebral autoregulation (sCA) index was evaluated via cerebral blood flow velocities (CBFv). Piglets with ICPs ≤ 25 and > 25 mmHg were considered as group 1 and 2, respectively. Continuous variables were evaluated using the Kolmogorov-Smirnov goodness-of-fit test. The main parameters were collected before and after ICH induction and compared using two-factor mixed-design ANOVAs with the factor of experimental group (mild and severe ICH).
In group 1 (ICP ≤ 25 mmHg), there were significant differences in sCA ( = .01) and ICP ( = .0002) between the basal and balloon inflation conditions. In group 2 (ICP > 25 mmHg), there were significant differences in CBFv ( = .0072), the sCA index ( = .0001) and ICP ( = .00001) between the basal and balloon inflation conditions.
We conclude that intracranial hypertension may have a direct effect on sCA.
分析轻、重度颅内高压对脑自动调节（CA）的影响。
通过颅内压（ICP）导管监测杜洛克小猪。通过将膀胱导管插入顶叶向颅内输注 4 或 7ml 生理盐水来诱导颅内高压。通过脑血流速度（CBFv）评估静态脑自动调节（sCA）指数。将 ICP 分别为≤25mmHg 和>25mmHg 的小猪分别归入组 1 和组 2。使用 Kolmogorov-Smirnov 拟合优度检验评估连续变量。在 ICH 诱导前后收集主要参数，并使用双因素混合设计 ANOVA 比较实验组（轻、重度 ICH）的因素。
在组 1（ICP≤25mmHg）中，在基础状态和球囊充气状态下，sCA（ = 0.01）和 ICP（ = 0.0002）有显著差异。在组 2（ICP>25mmHg）中，在基础状态和球囊充气状态下，CBFv（ = 0.0072）、sCA 指数（ = 0.0001）和 ICP（ = 0.00001）有显著差异。
我们得出结论，颅内高压可能对 sCA 有直接影响。
