Laboratory of Protein Biochemistry, Biochemistry Department, Manipur University, Canchipur, Imphal 795003, India.
Curr Pharm Biotechnol. 2020;21(14):1444-1450. doi: 10.2174/1389201021666200730123330.
Lectins are class of proteins characterized by their ability to selectively bind carbohydrate moieties of glycoproteins. Many invertebrate lectins, especially derived from hemolymph, are being purified, and yet their functions and medical applications are subjects of major interest.
Hemolymph lectins in invertebrates play a major role in protecting against many pathogens and microbes. Further, many hemolymph lectins show anticancer properties towards various cancer cell lines, which expresses globotriaosyl ceramides on their cell surface.
These vast repertoires of hemolymph lectins in recognizing and inhibiting the growth of various harmful microbes and cancerous cells have spurred the biochemist to use them in histochemical and cytochemical studies.
The present review will address the biological roles and biomedical applications of hemolymph lectin.
凝集素是一类能够特异性结合糖蛋白中糖基部分的蛋白质。许多无脊椎动物凝集素,特别是来源于血淋巴的凝集素,正在被纯化,而它们的功能和医学应用是主要关注的课题。
无脊椎动物血淋巴中的凝集素在抵抗多种病原体和微生物方面发挥着重要作用。此外,许多血淋巴凝集素对各种癌细胞系具有抗癌特性,这些癌细胞系在其细胞表面表达神经节苷脂 GM3。
这些丰富的血淋巴凝集素在识别和抑制各种有害微生物和癌细胞生长方面的作用,促使生物化学家在组织化学和细胞化学研究中使用它们。
本综述将讨论血淋巴凝集素的生物学作用和生物医学应用。