Eze Cosmas Chinweike, Ezeokonkwo Mercy Amarachukwu, Ezema Benjamin Ebere, Onoabedje Abraham Efeturi, Ugwu David Izuchukwu
Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, Enugu State 410001, Nigeria.
Department of Pure & Industrial Chemistry, University of Nigeria, Nsukka, Enugu State 410001, Nigeria.
Mini Rev Med Chem. 2021;21(11):1270-1287. doi: 10.2174/1389557520666200730154458.
Coumarin, sulphonamide, and amide scaffolds exhibit diverse pharmacological features and constitute an important class of therapeutic agents. In this review, we have discussed the synthesis, biological properties, and SAR of coumarins containing sulphonamide or amide group in the last seven years. Many reviews on the therapeutic activities of coumarins, sulphonamides, and amides have been published. Hence the authors focused on coumarin-linked sulphonamide or amide scaffolds. The review provides information on the synthetic route to new coumarins containing sulphonamide or amide groups with improved pharmacological properties.
香豆素、磺酰胺和酰胺骨架具有多种药理特性，是一类重要的治疗药物。在本综述中，我们讨论了过去七年中含磺酰胺或酰胺基团的香豆素的合成、生物学性质和构效关系。关于香豆素、磺酰胺和酰胺治疗活性的许多综述已经发表。因此，作者重点关注香豆素连接的磺酰胺或酰胺骨架。本综述提供了有关合成具有改善药理性质的含磺酰胺或酰胺基团的新型香豆素的路线的信息。
