Division of Endocrinology, Department of Internal Medicine, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Diabetes Investig. 2021 Apr;12(4):625-632. doi: 10.1111/jdi.13380. Epub 2020 Aug 28.
AIMS/INTRODUCTION: In this meta-analysis, we aimed to explore the association between bodyweight cycling (weight fluctuation) and the risk of developing diabetes.
We analyzed data from eligible cohort studies that assessed the association between weight cycling in adults and the risk of developing diabetes from online databases PubMed, Cochrane Library and EMBASE databases (1966 to April 2020). We pooled data using relative risks (RRs) with a random effects model.
A total of 14 studies involving 253,766 participants, including 8,904 diabetes events, were included. One study included eight independent reports, resulting in 21 reports in 14 studies. Summary analysis showed that individuals who suffered weight cycling had a higher risk of diabetes (RR 1.23. 95% confidence interval 1.07-1.41; P = 0.003). However, the association between weight cycling and the risk of developing diabetes was not observed in obese participants (body mass index ≥30 kg/m ; P = 0.08).
The present meta-analysis showed that weight cycling was a strong independent predictor of new-onset diabetes. Future studies are required to detect the causal links between weight cycling and the risk of developing diabetes.
目的/引言：在这项荟萃分析中，我们旨在探讨体重波动（体重循环）与糖尿病发病风险之间的关联。
我们分析了来自在线数据库 PubMed、Cochrane 图书馆和 EMBASE 数据库（1966 年至 2020 年 4 月）中评估成年人体重循环与糖尿病发病风险之间关联的合格队列研究的数据。我们使用随机效应模型汇总数据，使用相对风险（RR）进行分析。
共有 14 项研究纳入了 253766 名参与者，其中包括 8904 例糖尿病事件。一项研究包含 8 个独立报告，14 项研究中共有 21 个报告。综合分析显示，体重波动的个体发生糖尿病的风险更高（RR 1.23，95%置信区间 1.07-1.41；P=0.003）。然而，体重波动与肥胖参与者（体重指数≥30 kg/m2；P=0.08）发生糖尿病的风险之间没有关联。
本荟萃分析表明，体重波动是新发糖尿病的一个强有力的独立预测因素。需要进一步的研究来检测体重波动与糖尿病发病风险之间的因果关系。
