Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Brain Res. 2020 Nov 15;1747:147034. doi: 10.1016/j.brainres.2020.147034. Epub 2020 Jul 31.
Astrocyte elevated gene-1 (AEG-1) is an oncogene and a critical signaling molecule that has a wide variety of interactions with other oncogenes and tumor suppressor genes, leading to increasing malignant properties of malignant gliomas, such as invasion, angiogenesis, metastasis, and chemoresistance. Its overexpression is enhanced by many factors such as exposure of the cells to human immunodeficiency virus type 1 (HIV-1), HIV-1 envelop glycoprotein 120, hypoxia, or glucose deprivation. Thorough understanding of these interactions along with AEG-1 inducers and repressors is important in setting a successful treatment plan targeting this oncogene. Since its discovery in 2002, AEG-1 has made a significant impact in improving our understanding of mechanism of malignant tumors progression, such as breast carcinomas, melanoma, and malignant gliomas. Therefore, it has been a novel therapeutic target for the past two decades. Herein, we focus on the role of AEG-1 in malignant gliomas and its interaction with other signaling molecules.
星形胶质细胞上调基因-1（AEG-1）是一种癌基因和关键信号分子，与其他癌基因和肿瘤抑制基因有广泛的相互作用，导致恶性胶质瘤的恶性特性增加，如侵袭、血管生成、转移和化疗耐药。细胞暴露于人类免疫缺陷病毒 1 型（HIV-1）、HIV-1 包膜糖蛋白 120、缺氧或葡萄糖剥夺等多种因素可增强其过表达。彻底了解这些相互作用以及 AEG-1 的诱导剂和抑制剂对于制定针对该癌基因的成功治疗计划非常重要。自 2002 年发现以来，AEG-1 在提高我们对乳腺癌、黑色素瘤和恶性胶质瘤等恶性肿瘤进展机制的理解方面发挥了重要作用。因此，在过去的二十年中，它一直是一个新的治疗靶点。本文重点介绍了 AEG-1 在恶性胶质瘤中的作用及其与其他信号分子的相互作用。
