Liu Yanan, Liu Jiawei, Guo Xiaoping, Lin Ange, Wen Yayu, Chen Xu, Zhu Xufeng, Liu Jie, Luo Zhaohui
Department of Chemistry, College of Chemistry and Materials Science, 47885Jinan University, Guangzhou, China.
College of Pharmacy, 74716Guilin Medical University, Guangxi Guilin, China.
J Biomater Appl. 2021 Jan;35(6):696-708. doi: 10.1177/0885328220940541. Epub 2020 Aug 3.
Representative pathogenic bacteria such as () and () are widespread in nature and pose a threat to human health. To control the propagation of these pathogens from the source, the key is to design broad-spectrum antibacterial materials to reduce the serious damage of pathogenic bacteria. At present, more and more nanoparticles are widely researched and applied due to their multi-pathway antibacterial properties, such as regulating physiology, biochemistry and physical chemistry. In this work, we synthesized a uniformly dispersed and stable spherical nanoparticle (TiO@VO) synthesized by self-assembly of tianium dioxide and vanadium pentoxide. Based on its excellent photosensitive properties, TiO@VO nanoparticles have showed excellent antibacterial properties under the light irradiation due to the production of hydroxyl radicals in antibacterial and mechanism tests. In addtion, related cell and plant experiments have showed that TiO@VO nanoparticles are excellent biocompatible materials, it could be widely used in environmental pollution control, limiting the serious damage caused by pathogens.
代表性的致病细菌如（）和（）在自然界中广泛存在，对人类健康构成威胁。为了从源头上控制这些病原体的传播，关键是设计广谱抗菌材料以减少致病细菌的严重危害。目前，越来越多的纳米颗粒因其多途径抗菌特性而被广泛研究和应用，例如调节生理、生化和物理化学过程。在这项工作中，我们合成了一种通过二氧化钛和五氧化二钒自组装而成的均匀分散且稳定的球形纳米颗粒（TiO@VO）。基于其优异的光敏特性，TiO@VO纳米颗粒在抗菌和机理测试中由于产生羟基自由基而在光照下表现出优异的抗菌性能。此外，相关的细胞和植物实验表明TiO@VO纳米颗粒是优异的生物相容性材料，可广泛用于环境污染控制，限制病原体造成的严重危害。
