Department of Orthopedics, Huadong Hospital Affiliated To Fudan University, No. 221 Yan'an West Road, Jing'an District, Shanghai, 200040, China.
Sci Rep. 2020 Aug 3;10(1):13015. doi: 10.1038/s41598-020-70144-5.
We aimed to analyze the associations of bone mineral density (BMD) of femoral heads, age and gender, and compare the differences in BMD between fracture side and non-fracture side by "3D Spine Exam Analysis" module in QCT Pro software. In this study, we identified patients who had undergone quantitative computed tomography (QCT) examinations between March 2016 and July 2018 and measured their trabecular volumetric BMD (vBMD) of femoral heads. This retrospective study enrolled 367 subjects. A total of 149 participants with images were randomly selected to verify the repeatability of this method. The relationship among the vBMD, age and gender was analyzed (n = 367), and the difference of vBMD between non-fracture side and fracture side were studied in subjects (n = 75) with low-energy hip fracture on one side and compared the image quality of bilateral hip joints. The intraclass correlation coefficients (ICCs) between the results measured by 2 operators and the results measured by the same operator showed excellent agreement (ICCs > 0.9). Multivariate regression equation of vBMD of femoral head, age and gender showed statistical significance (P < 0.05). vBMD showed negative correlation with age (P < 0.05), and showed no statistically significant relation with gender (P > 0.05). vBMD of non-fracture side was higher than that of fracture side, but the difference was statistically significant only at the middle layer (P < 0.05). In conclusions, the vBMD of femoral head as measured by "3D Spine Exam Analysis" module in QCT Pro software showed good repeatability. The trabecular vBMD of femoral head was negatively correlated with age, and not related with gender. The vBMD of femoral head was higher on non-fracture side than that on the fracture side.
我们旨在通过 QCT Pro 软件的“3D SpineExamAnalysis”模块分析股骨头骨密度（BMD）与年龄和性别之间的关系，并比较骨折侧和非骨折侧 BMD 的差异。在这项研究中，我们确定了 2016 年 3 月至 2018 年 7 月期间接受定量计算机断层扫描（QCT）检查的患者，并测量了他们股骨头的小梁体积 BMD（vBMD）。这项回顾性研究共纳入 367 例患者。随机选择了 149 名有图像的参与者来验证该方法的重复性。分析了 vBMD 与年龄和性别之间的关系（n=367），并研究了一侧低能量髋部骨折的 75 例患者非骨折侧和骨折侧 vBMD 的差异，并比较了双侧髋关节的图像质量。两名操作员测量结果之间的组内相关系数（ICCs）和同一名操作员测量结果之间的 ICCs 均显示出极好的一致性（ICCs>0.9）。股骨头 vBMD、年龄和性别多变量回归方程具有统计学意义（P<0.05）。vBMD 与年龄呈负相关（P<0.05），与性别无统计学相关性（P>0.05）。非骨折侧 vBMD 高于骨折侧，但仅在中层差异有统计学意义（P<0.05）。结论，QCTPro 软件“3D SpineExamAnalysis”模块测量的股骨头 vBMD 具有良好的可重复性。股骨头小梁 vBMD 与年龄呈负相关，与性别无关。非骨折侧股骨头 vBMD 高于骨折侧。
