Kethawath Shanti Mohan, Jain Raka, Dhawan Anju, Sarkar Siddharth, Kumar Mukesh
Department of Psychiatry, National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS) , New Delhi, India.
Lab Technician of National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS) , New Delhi, India.
J Psychoactive Drugs. 2020 Nov-Dec;52(5):440-446. doi: 10.1080/02791072.2020.1795327. Epub 2020 Aug 4.
Brain-Derived Neurotrophic Factor (BDNF) is a neuropeptide that plays an important role in Central Nervous System development, plasticity, learning, and memory. Its role has been explored in alcohol-dependent patients, though the results have been inconclusive. Thus, we aimed to compare serum BDNF levels in alcohol-dependent patients during withdrawal with age and gender matched controls, and assess changes in BDNF levels in the initial abstinence period. BDNF levels of alcohol-dependent patients ( = 25) were compared with controls ( = 25) at baseline. Additionally, BDNF levels were measured in cases on days 5 and 10 of inpatient detoxification. BDNF levels of controls did not differ with cases on day 1, 5, or 10. But BDNF levels increased significantly during alcohol abstinence from baseline to day 10 (Pillai's Trace = 3.753, = .039, partial η = 0.246), which may suggest its protective role. Thus, serum BDNF values may be potentially used as a biomarker to assess the abstinence state. However, longitudinal studies in different body samples is essential to better understand the role of BDNF in alcohol dependence.
脑源性神经营养因子（BDNF）是一种神经肽，在中枢神经系统发育、可塑性、学习和记忆中发挥着重要作用。其在酒精依赖患者中的作用已得到探索，不过结果尚无定论。因此，我们旨在比较酒精依赖患者戒断期间与年龄和性别匹配的对照组的血清BDNF水平，并评估戒断初期BDNF水平的变化。在基线时，比较了25例酒精依赖患者与25例对照组的BDNF水平。此外，在住院戒毒的第5天和第10天测量了患者的BDNF水平。对照组在第1天、第5天或第10天的BDNF水平与患者无差异。但从基线到第10天戒酒期间，BDNF水平显著升高（皮莱迹=3.753，P=0.039，偏η=0.246），这可能表明其具有保护作用。因此，血清BDNF值可能潜在地用作评估戒酒状态的生物标志物。然而，对不同身体样本进行纵向研究对于更好地理解BDNF在酒精依赖中的作用至关重要。
