E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya Str., 630055 Novosibirsk, Russia.
Mar Drugs. 2020 Aug 2;18(8):410. doi: 10.3390/md18080410.
Several experimental studies have recently demonstrated that temporary autonomic block using botulinum toxin (BoNT/A1) might be a novel option for the treatment of atrial fibrillation. However, the assessment of antiarrhythmic properties of BoNT has so far been limited, relying exclusively on vagal stimulation and rapid atrial pacing models. The present study examined the antiarrhythmic effect of specially formulated BoNT/A1-chitosan nanoparticles (BTN) in calcium chloride-, barium chloride- and electrically induced arrhythmia rat models. BTN enhanced the effect of BoNT/A1. Subepicardial injection of BTN resulted in a significant antiarrhythmic effect in investigated rat models. BTN formulation antagonizes arrhythmia induced by the activation of Ca, K and Na channels.
最近的几项实验研究表明，使用肉毒杆菌毒素（BoNT/A1）进行暂时的自主神经阻断可能是治疗心房颤动的一种新选择。然而，到目前为止，BoNT 的抗心律失常特性的评估仅限于通过迷走神经刺激和快速心房起搏模型来进行。本研究在氯化钙、氯化钡和电诱导心律失常大鼠模型中检查了特制的 BoNT/A1-壳聚糖纳米颗粒（BTN）的抗心律失常作用。BTN 增强了 BoNT/A1 的作用。BTN 的皮下注射在心电研究模型中产生了显著的抗心律失常作用。BTN 配方拮抗由 Ca、K 和 Na 通道激活引起的心律失常。
