Bermingham Eden, Davis Jennifer L, Whittem Ted
Animal Clinical Investigation LLC, Chevy Chase, MD, USA.
Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.
Equine Vet J. 2020 Sep;52(5):643-650. doi: 10.1111/evj.13312.
The goal of this editorial is to discuss best practice design, execution and reporting of a pharmacokinetic (PK) study in horses. Our target readers are clinicians who plan to perform this type of research, in a field, clinic or research setting but we also hope that this article might help readers of such work to appraise the articles and understand the quality of the studies. Our emphasis will be on appropriate study design and analytical method, drug and drug formulation choice and route of administration, animal choice, sample collection, storage and shipping, and reporting, rather than the PK data analysis itself.
本社论的目的是讨论马匹药代动力学(PK)研究的最佳实践设计、实施和报告。我们的目标读者是计划在野外、诊所或研究环境中开展此类研究的临床医生,但我们也希望本文能帮助此类研究的读者评估文章并了解研究质量。我们将重点关注适当的研究设计和分析方法、药物及药物制剂的选择和给药途径、动物选择、样本采集、储存和运输以及报告,而非药代动力学数据分析本身。