Tóth-Vajna Zsombor, Tóth-Vajna Gergely, Gombos Zsuzsanna, Szilágyi Brigitta, Járai Zoltán, Sótonyi Péter
Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika, Érsebészeti Tanszék,Semmelweis Egyetem, Budapest.
Magatartástudományi Intézet,Semmelweis Egyetem, Budapest.
Orv Hetil. 2020 Aug;161(33):1382-1390. doi: 10.1556/650.2020.31756.
The screening tool for diagnosing lower extremity arterial disease (LEAD) is the assessment of the ankle-brachial index (ABI). In patients at risk for LEAD, the purpose of screening is to avoid major adverse limb events, such as amputation. However, resting ABI can easily produce a false negative result.
In light of this, our goal was to test the usefulness of an easily performed, fast and cost-effective screening method and to determine the proportion of subjects without definitive diagnoses among patients screened in general practice (with special attention to groups having negative ABI with symptoms and patients with non-compressible arteries).
680 patients were screened from the region of Northern Hungary. We used the Edinburgh Questionnaire, recorded medical histories, major risk factors, current complaints, and medication. Physical examinations were performed, including ABI testing.
34% complained about lower extremity claudication; 23% had abnormal ABI values; 14% of the patients within the normal ABI range had complaints of dysbasia; 12% were in the non-compressible artery group. The ABI-negative symptomatic group's risk factor profile showed a close similarity to the clear LEAD-positive and non-compressible artery groups.
The percentage of LEAD could be higher than the number of patients diagnosed by ABI screening. Nearly a quarter of the population fell into the non-compressible artery and ABI-negative symptomatic groups. When screening purposely for LEAD, these patients deserve special attention due to the insufficient selectivity and sensitivity of measurements. If there is a high clinical suspicion of LEAD in spite of normal ABI values, further assessment may be considered. Orv Hetil. 2020; 161(33): 1381-1389.
诊断下肢动脉疾病(LEAD)的筛查工具是踝臂指数(ABI)评估。在有LEAD风险的患者中,筛查的目的是避免严重肢体不良事件,如截肢。然而,静息ABI很容易产生假阴性结果。
鉴于此,我们的目标是测试一种易于执行、快速且经济高效的筛查方法的实用性,并确定在全科医疗筛查的患者中未明确诊断的受试者比例(特别关注ABI阴性且有症状的群体以及动脉不可压缩的患者)。
从匈牙利北部地区筛查了680名患者。我们使用了爱丁堡问卷,记录了病史、主要危险因素、当前症状和用药情况。进行了体格检查,包括ABI测试。
34%的患者主诉下肢间歇性跛行;23%的患者ABI值异常;在ABI正常范围内的患者中有14%主诉步态障碍;12%属于动脉不可压缩组。ABI阴性有症状组的危险因素特征与明确的LEAD阳性组和动脉不可压缩组非常相似。
LEAD的实际比例可能高于通过ABI筛查诊断出的患者数量。近四分之一的人群属于动脉不可压缩组和ABI阴性有症状组。在针对性筛查LEAD时,由于测量的选择性和敏感性不足,这些患者值得特别关注。如果尽管ABI值正常但临床高度怀疑LEAD,可考虑进一步评估。《匈牙利医学周报》。2020年;161(33): 1381 - 1389。