Mazurenko Elena, Rymar Oksana, Shcherbakova Liliya, Mazdorova Ekaterina, Malyutina Sofia
Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630089, Russia.
Novosibirsk Research Institute of Traumatology and Orthopedics named after Ya. L. Tsivyan, Novosibirsk 630112, Russia.
J Pers Med. 2020 Jul 31;10(3):77. doi: 10.3390/jpm10030077.
The reduction in bone and muscle mass increases in menopausal women and poses a threat to the loss of - in the elderly. The aim of the study was to assess the frequency of osteoporotic forearm fractures (OFF) in postmenopausal women and to study their association with risk factors for chronic non-communicable diseases (NCD). The study was based on the Russian arm of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project (Novosibirsk). In a subsample of postmenopausal women aged 55-84 years old (n = 2005), we assessed the history of OFF during the last 3 years and risk factors for fracture and common NCD/. Cross-sectional associations between OFF history and potential determinants were analyzed using multivariable-adjusted logistic regression. A history of OFF in the last 3 years was found in 3.9% women. In a multivariable-adjusted model, the risk of OFF was directly associated with smoking in the past (OR = 2.23; 95% Cl 1.10-4.55), total cholesterol level higher than 200 mg/dL (OR = 1.98; 95% Cl 1.19-3.29), and it was inversely associated with body mass index (OR = 0.91; 95% Cl 0.86-0.96). In studied population sample of postmenopausal women the cross-sectional determinants of osteoporotic forearm fractures were smoking in the past and high total cholesterol value; body mass index protectively related to the risk of osteoporotic fractures. These findings might have implications for fracture prevention in postmenopausal women.
绝经后女性的骨质和肌肉量减少加剧，这对老年人的身体机能丧失构成威胁。本研究旨在评估绝经后女性骨质疏松性前臂骨折（OFF）的发生频率，并研究其与慢性非传染性疾病（NCD）风险因素的关联。该研究基于东欧健康、酒精与社会心理因素（HAPIEE）项目（新西伯利亚）的俄罗斯部分。在一个55 - 84岁绝经后女性的子样本（n = 2005）中，我们评估了过去3年的OFF病史以及骨折和常见NCD的风险因素。使用多变量调整逻辑回归分析OFF病史与潜在决定因素之间的横断面关联。在3.9%的女性中发现过去3年有OFF病史。在多变量调整模型中，OFF风险与过去吸烟直接相关（OR = 2.23；95% CI 1.10 - 4.55），总胆固醇水平高于200 mg/dL（OR = 1.98；95% CI 1.19 - 3.29），并且与体重指数呈负相关（OR = 0.91；95% CI 0.86 - 0.96）。在绝经后女性的研究人群样本中，骨质疏松性前臂骨折的横断面决定因素是过去吸烟和高总胆固醇值；体重指数与骨质疏松性骨折风险呈保护性相关。这些发现可能对绝经后女性的骨折预防具有启示意义。
