Center of Oral Clinical Examination, Hiroshima University Hospital, Japan
Department of Periodontal Medicine, Graduate School of Biomedical & Sciences, Hiroshima University, Japan
Curr HIV Res. 2020;18(6):475-479. doi: 10.2174/1570162X18666200804151118.
Dental professionals have so many opportunities to use injection needles and sharp instruments during dental treatment that they face an increased risk of needlestick injuries. This retrospective study reports the utilization and clinical outcomes of occupational post-exposure prophylaxis (PEP) with anti-retroviral agents after being potentially exposed to HIV at the dental departments of Hiroshima University Hospital.
This study reports the utilization and clinical outcomes of occupational post-exposure prophylaxis (PEP) with antiretroviral agents after being potentially exposed to HIV at dental departments of Hiroshima University Hospital.
Data on the clinical status of HIV-infected source patients and information on HIV-exposed dental professionals from 2007 to 2018 were collected.
Five dentists with an average experience of 5.6 years (1-15 years) were exposed. The averaged CD4-positive cell number and HIV-RNA load were 1176 (768-1898) /μl and less than 20 copies/ml, respectively, in all the patients. Two of the five HIV exposed dentists received PEP. Three months after the exposures, all of their results were negative in HIV antibody/antigen tests.
; These data might support the concept of "undetectable equals untransmittable", although HIV exposure in this study was not through sexual transmission.
牙科专业人员在牙科治疗过程中会有很多机会使用注射针和锐器，因此面临着增加的针刺伤风险。本回顾性研究报告了广岛大学医院牙科部门发生潜在 HIV 暴露后，使用抗逆转录病毒药物进行职业性接触后预防（PEP）的利用情况和临床结局。
本研究报告了广岛大学医院牙科部门发生潜在 HIV 暴露后，使用抗逆转录病毒药物进行职业性接触后预防（PEP）的利用情况和临床结局。
收集了 2007 年至 2018 年期间 HIV 感染源患者的临床状况数据和 HIV 暴露牙科专业人员的信息。
5 名平均经验 5.6 年（1-15 年）的牙医暴露。所有患者的平均 CD4+阳性细胞数和 HIV-RNA 载量分别为 1176（768-1898）/μl 和小于 20 拷贝/ml。5 名 HIV 暴露牙医中有 2 名接受了 PEP。暴露后 3 个月，他们所有人的 HIV 抗体/抗原检测结果均为阴性。
尽管本研究中的 HIV 暴露不是通过性传播，但这些数据可能支持“检测不到等于不传播”的概念。
