t(15;17)(q22;q12) 阳性急性早幼粒细胞白血病患者的生存情况：伊朗东北部的一项研究
The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran.
作者信息
Ayatollahi Hossein, Bazi Ali, Sadeghian Mohammad Hadi, Fani Ali, Siyadat Payam, Sheikhi Maryam, Sargazi-Aval Omolbanin
机构信息
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran.
出版信息
Iran J Pathol. 2020 Summer;15(3):175-181. doi: 10.30699/ijp.2020.101417.2007. Epub 2020 Apr 21.
BACKGROUND & OBJECTIVE: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML). Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran.
METHODS
Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was obtained from archived medical records. Statistical analysis was performed by SPSS 18 software using log-ranked test and Kaplan Maier survival analysis.
RESULTS
Females and males comprised 49% and 51%, respectively. The mean age at diagnosis was 34.3 14.1 years old. During the study period, 17 demises occurred in males, while this number was 7 in females. The mean survival of patients (month) was 23.22 3.57 (95% CI: 16.21 30.2). The five-year survival rate obtained 30%. Regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count <10 /l (48%), and platelet count >140 /l (100%).
CONCLUSION
Younger age, lower WBC count and higher platelet count were significantly associated with longer survival in AML patients with t(15;17)(q22; q12).
背景与目的
伴有t(15;17)(q22;q12)的急性早幼粒细胞白血病（APL）是急性髓系白血病（AML）中一种相对常见的亚型。在此，我们的目的是确定伊朗东北部地区患有这种白血病患者的生存率。
方法
评估42例伴有t(15;17)(q22;q12)的APL患者的生存率。临床信息从存档的病历中获取。使用SPSS 18软件通过对数秩检验和Kaplan - Maier生存分析进行统计分析。
结果
女性和男性分别占49%和51%。诊断时的平均年龄为34.3±14.1岁。在研究期间，男性中有17例死亡，而女性为7例。患者的平均生存期（月）为23.22±3.57（95%可信区间：16.21 - 30.2）。五年生存率为30%。关于人口统计学和临床特征，年龄在20 - 35岁的患者（47.6%）、男性（51%）、白细胞计数<10×10⁹/L（48%）以及血小板计数>140×10⁹/L（100%）的患者五年生存率最高。
结论
年龄较小、白细胞计数较低和血小板计数较高与伴有t(15;17)(q22;q12)的AML患者更长的生存期显著相关。
Zotero 插件