Anupam Biswas, Shivaprasad Channabasappa, Vijaya Sarathi, Sridevi Atluri, Aiswarya Yalamanchi, Nikhil Kumar
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1299-1304. doi: 10.1016/j.dsx.2020.07.006. Epub 2020 Jul 18.
To determine the prevalence of hypogonadism among Indian men with and without type 2 diabetes mellitus (T2DM) and evaluate its association with various metabolic parameters.
One hundred fifty consecutive men with T2DM, aged 25-70 years, and one hundred age-matched healthy men without diabetes were included. The free testosterone (FT) level was calculated using the total testosterone (TT), sex hormone-binding globulin (SHBG), and albumin levels in serum. Patients with a calculated FT level <6.35 ng/dL and a positive response on the androgen deficiency in aging male questionnaire (ADAM) were diagnosed with hypogonadism.
The prevalence of hypogonadism was 17.3% and 10% in men with and without T2DM, respectively. The body mass index (BMI) and the mean levels of follicle-stimulating hormone (FSH), TT, SHBG, Triglycerides (TG), and FT were significantly different between the groups. The mean BMI and TG levels were significantly higher in patients with T2DM than in those without. Both groups showed a significant negative correlation between the BMI and SHBG level.
The hypogonadism prevalence was higher in patients with T2DM than in those without, although the difference did not reach statistical significance.
确定患有和未患有2型糖尿病（T2DM）的印度男性性腺功能减退的患病率，并评估其与各种代谢参数的关联。
纳入150名年龄在25 - 70岁之间的连续T2DM男性患者，以及100名年龄匹配的无糖尿病健康男性。使用血清中的总睾酮（TT）、性激素结合球蛋白（SHBG）和白蛋白水平计算游离睾酮（FT）水平。计算出的FT水平<6.35 ng/dL且老年男性雄激素缺乏问卷（ADAM）呈阳性反应的患者被诊断为性腺功能减退。
患有和未患有T2DM的男性中，性腺功能减退的患病率分别为17.3%和10%。两组之间的体重指数（BMI）以及促卵泡生成素（FSH）、TT、SHBG、甘油三酯（TG）和FT的平均水平存在显著差异。T2DM患者的平均BMI和TG水平显著高于无T2DM的患者。两组的BMI和SHBG水平均呈显著负相关。
T2DM患者的性腺功能减退患病率高于无T2DM的患者，尽管差异未达到统计学意义。
