Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1307-1314. doi: 10.1016/j.dsx.2020.07.031. Epub 2020 Jul 18.
Today, it has been shown that diabetes mellitus (DM) can affect male fertility. Glucose metabolism is a vital process in spermatogenesis that is impacted by diabetes condition. But the mechanisms by which DM causes male infertility are not wholly clarified. The aim of this review is to provide brief information about the influence of hyperglycemia on male fertility and specific emphasis on the molecular signaling pathway that is involved.
Broad literature search in the electronic database "Pubmed", "Google Scholar", the website of "World Health Organization" (WHO) and Control Disease and Prevention (CDC) took place. There was no time restriction. A key criterion for the selection of articles was English and language. Finally, one hundred thirty seven articles were included in the review.
Diabetes mellitus affects many signaling pathways that involved in the spermatogenesis. It seems that increased ROS and oxidative stress in the diabetes is the beginning of all fertility problems and affects all of involved signaling pathways in the spermatogenesis.
It seems that there was strong interconnected between oxidative stress and all of involved signaling pathways in the reproductive problems in diabetes. So, approaches that diminish oxidative stress in the testis can be effective in improving diabetes related infertility complications.
如今，糖尿病（DM）会影响男性生育力已得到证实。葡萄糖代谢是精子发生过程中的一个重要过程，会受到糖尿病状况的影响。但是，DM 导致男性不育的机制尚未完全阐明。本综述的目的是提供有关高血糖对男性生育力影响的简要信息，并特别强调所涉及的分子信号通路。
在电子数据库“Pubmed”、“Google Scholar”、世界卫生组织（WHO）和疾病控制与预防中心（CDC）网站上进行了广泛的文献检索。没有时间限制。选择文章的一个关键标准是英语和语言。最后，有 137 篇文章被纳入综述。
糖尿病会影响许多参与精子发生的信号通路。似乎糖尿病中 ROS 和氧化应激的增加是所有生育问题的开始，并影响精子发生中涉及的所有信号通路。
似乎在糖尿病引起的生殖问题中，氧化应激与所有涉及的信号通路之间存在着强烈的相互联系。因此，减少睾丸氧化应激的方法可能对改善与糖尿病相关的不育并发症有效。
