Wang HongZhou, Wang WanHua, Shi HaiCun, Han LiJian, Pan PingLei
Department of Neurology, Kunshan Hospital, Affiliated to Jiangsu University, Kunshan.
Department of Neurology.
Medicine (Baltimore). 2020 Jul 31;99(31):e21458. doi: 10.1097/MD.0000000000021458.
Parkinson disease (PD) is a common neurodegenerative disorder. Elevations of neurofilament light chain (NfL) concentrations in the cerebrospinal fluid (CSF) and blood are a marker of neuronal/axonal injury and degeneration. However, CSF and blood NfL alterations in patients with PD from existing studies remain inconclusive. To better understand these conflicting data, we will conduct a meta-analysis.
We will comprehensively search PubMed, Embase, and Web of Science databases from each database's inception to 7th June, 2020. This protocol will conform to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols. We will only include original studies published in English that evaluated differences of NfL concentrations in the CSF or blood between idiopathic PD patients and healthy controls. The Newcastle-Ottawa Scale will be used to evaluate the quality of the included studies. Meta-analyses will be carried out using the STATA software version 13.0. Between-group difference of NfL concentrations in the CSF and blood will be expressed as the weighted standardized mean difference. A random-effects model will be used. Supplementary analyses, such as heterogeneity analysis, sensitivity analysis, publication bias, subgroup analysis, and meta-regression analysis will be performed.
The meta-analysis will provide the differences of NfL concentrations in the CSF and blood between patients with PD and healthy controls and will show the magnitudes of their effect sizes.
This meta-analysis will provide the evidence of NfL concentrations in the CSF and blood in PD and we hope that our study has an important impact on clinical practice.
INPLASY202060025.
帕金森病（PD）是一种常见的神经退行性疾病。脑脊液（CSF）和血液中神经丝轻链（NfL）浓度升高是神经元/轴突损伤和变性的标志物。然而，现有研究中PD患者脑脊液和血液中NfL的变化尚无定论。为了更好地理解这些相互矛盾的数据，我们将进行一项荟萃分析。
我们将全面检索PubMed、Embase和Web of Science数据库，检索时间从每个数据库创建至2020年6月7日。本方案将符合系统评价和荟萃分析方案的首选报告项目。我们将只纳入以英文发表的、评估特发性PD患者与健康对照者脑脊液或血液中NfL浓度差异的原始研究。将使用纽卡斯尔-渥太华量表来评估纳入研究的质量。将使用STATA 13.0软件进行荟萃分析。脑脊液和血液中NfL浓度的组间差异将表示为加权标准化平均差。将使用随机效应模型。将进行补充分析，如异质性分析、敏感性分析、发表偏倚分析、亚组分析和荟萃回归分析。
荟萃分析将提供PD患者与健康对照者脑脊液和血液中NfL浓度的差异，并将显示其效应大小的幅度。
这项荟萃分析将提供PD患者脑脊液和血液中NfL浓度的证据，我们希望我们的研究对临床实践产生重要影响。
INPLASY202060025。
